Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-02-22
2005-02-22
Chang, Ceila (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S217030, C514S229200, C514S230500, C514S231200, C514S259500, C514S317000, C514S358000, C514S373000, C514S418000, C514S426000, C546S125000, C546S207000, C546S208000, C546S209000, C546S215000, C546S347000, C544S067000, C544S090000, C544S111000, C544S253000, C544S359000, C540S524000, C548S207000, C548S486000, C548S566000
Reexamination Certificate
active
06858623
ABSTRACT:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.
REFERENCES:
patent: 4734425 (1988-03-01), Nakane et al.
patent: 4749715 (1988-06-01), Hall
patent: 4797202 (1989-01-01), Klimpel et al.
patent: 4957932 (1990-09-01), Young et al.
patent: 4962117 (1990-10-01), Young et al.
patent: 5196291 (1993-03-01), Okada et al.
patent: 5218123 (1993-06-01), Horwell et al.
patent: 5250732 (1993-10-01), Kogan et al.
patent: 5328803 (1994-07-01), Fujikura et al.
patent: 5346907 (1994-09-01), Kerwin, Jr. et al.
patent: 5461176 (1995-10-01), Sun et al.
patent: 5504109 (1996-04-01), Seitz et al.
patent: 5514778 (1996-05-01), Hammond et al.
patent: 5633248 (1997-05-01), Kato et al.
patent: 5691368 (1997-11-01), Peet et al.
patent: 5710129 (1998-01-01), Lynch et al.
patent: 5744451 (1998-04-01), Allen et al.
patent: 5756528 (1998-05-01), Anthony et al.
patent: 5776718 (1998-07-01), Palmer et al.
patent: 5847135 (1998-12-01), Bemis et al.
patent: 5872122 (1999-02-01), Bovy et al.
patent: 5976858 (1999-11-01), Palmer et al.
patent: 3827727 (1990-02-01), None
patent: 4343528 (1993-12-01), None
patent: 4225487 (1994-02-01), None
patent: 4303145 (1994-08-01), None
patent: 4321897 (1995-01-01), None
patent: 19609955 (1997-09-01), None
patent: 19653647 (1998-06-01), None
patent: 0 115 472 (1984-08-01), None
patent: 0294668 (1988-12-01), None
patent: 0308885 (1989-03-01), None
patent: 0314060 (1989-05-01), None
patent: 0318083 (1989-05-01), None
patent: 0336356 (1989-10-01), None
patent: 0374098 (1990-06-01), None
patent: 0398072 (1990-11-01), None
patent: 0483667 (1992-05-01), None
patent: 0506008 (1992-09-01), None
patent: 0529737 (1993-03-01), None
patent: 0533244 (1993-03-01), None
patent: 0542463 (1993-05-01), None
patent: 0547699 (1993-06-01), None
patent: 587110 (1994-03-01), None
patent: 0 604 182 (1994-06-01), None
patent: 0611756 (1994-08-01), None
patent: 0611756 (1994-08-01), None
patent: 0644198 (1995-03-01), None
patent: 0649057 (1995-04-01), None
patent: 0 652 229 (1995-05-01), None
patent: 0672654 (1995-09-01), None
patent: 805147 (1997-11-01), None
patent: 810206 (1997-12-01), None
patent: 0 838 471 (1998-04-01), None
patent: 844248 (1998-05-01), None
patent: 844248 (1998-05-01), None
patent: 846464 (1998-06-01), None
patent: 846464 (1998-06-01), None
patent: 897908 (1999-02-01), None
patent: 2694006 (1994-01-01), None
patent: 662788 (1965-08-01), None
patent: 68010619 (1968-05-01), None
patent: 6358346 (1988-03-01), None
patent: 63301868 (1988-12-01), None
patent: 3002872 (1991-01-01), None
patent: 6003787 (1994-01-01), None
patent: 6051451 (1994-02-01), None
patent: 6145173 (1994-05-01), None
patent: 6293772 (1994-10-01), None
patent: 6340643 (1994-12-01), None
patent: 7-101959 (1995-04-01), None
patent: 7285931 (1995-10-01), None
patent: 8248579 (1996-09-01), None
patent: 11100373 (1999-04-01), None
patent: WO-8505031 (1985-11-01), None
patent: WO 8808717 (1988-11-01), None
patent: WO 8910920 (1989-11-01), None
patent: WO 9013561 (1990-11-01), None
patent: WO 9119733 (1991-12-01), None
patent: WO 9201675 (1992-02-01), None
patent: WO 9214465 (1992-09-01), None
patent: WO 9217453 (1992-10-01), None
patent: WO 9221361 (1992-12-01), None
patent: WO 9222570 (1992-12-01), None
patent: WO 9305444 (1993-03-01), None
patent: WO 9312075 (1993-06-01), None
patent: WO 9314069 (1993-07-01), None
patent: WO 9400435 (1994-01-01), None
patent: WO 9406757 (1994-03-01), None
patent: WO 9407841 (1994-04-01), None
patent: WO 9421657 (1994-09-01), None
patent: WO 9422911 (1994-10-01), None
patent: WO 9425432 (1994-10-01), None
patent: WO 9501344 (1995-01-01), None
patent: WO 9506029 (1995-03-01), None
patent: WO 9509838 (1995-04-01), None
patent: WO 9512611 (1995-05-01), None
patent: WO 9515749 (1995-06-01), None
patent: WO 9523222 (1995-08-01), None
patent: WO 9524382 (1995-09-01), None
patent: WO 9529899 (1995-11-01), None
patent: WO 9533728 (1995-12-01), None
patent: WO 9535308 (1995-12-01), None
patent: WO 9607638 (1996-03-01), None
patent: WO 9610559 (1996-04-01), None
patent: WO 9612499 (1996-05-01), None
patent: WO 9613502 (1996-05-01), None
patent: WO 9616940 (1996-06-01), None
patent: WO 9620725 (1996-07-01), None
patent: WO 9620949 (1996-07-01), None
patent: WO 9622970 (1996-08-01), None
patent: WO 9626194 (1996-08-01), None
patent: WO 9630353 (1996-10-01), None
patent: WO 9633168 (1996-10-01), None
patent: WO 9633170 (1996-10-01), None
patent: WO 9633211 (1996-10-01), None
patent: WO 9637499 (1996-11-01), None
patent: WO 9639137 (1996-12-01), None
patent: WO 9639384 (1996-12-01), None
patent: WO 9640647 (1996-12-01), None
patent: WO 9640737 (1996-12-01), None
patent: WO 9640741 (1996-12-01), None
patent: WO 9640742 (1996-12-01), None
patent: WO 9640744 (1996-12-01), None
patent: WO 9640751 (1996-12-01), None
patent: WO 9640752 (1996-12-01), None
patent: WO 9640753 (1996-12-01), None
patent: WO 9701275 (1997-01-01), None
patent: WO 9710219 (1997-03-01), None
patent: WO 9719908 (1997-06-01), None
patent: WO 9722618 (1997-06-01), None
patent: WO 9722619 (1997-06-01), None
patent: WO 9722621 (1997-06-01), None
patent: WO 9722621 (1997-06-01), None
patent: WO 9724343 (1997-07-01), None
patent: WO 9726246 (1997-07-01), None
patent: WO 9727200 (1997-07-01), None
patent: WO 9727220 (1997-07-01), None
patent: WO 9731016 (1997-08-01), None
patent: WO 9731016 (1997-08-01), None
patent: WO 9745016 (1997-12-01), None
patent: WO 9746518 (1997-12-01), None
patent: WO 9804278 (1998-02-01), None
patent: WO 9804518 (1998-02-01), None
patent: WO 9814450 (1998-04-01), None
patent: WO 9817679 (1998-04-01), None
patent: WO 9821199 (1998-05-01), None
patent: WO 9821199 (1998-05-01), None
patent: WO 9822433 (1998-05-01), None
patent: WO 9825617 (1998-06-01), None
patent: WO 9826654 (1998-06-01), None
patent: WO 9826654 (1998-06-01), None
patent: WO 9828269 (1998-07-01), None
patent: WO 9838177 (1998-09-01), None
patent: WO 9847863 (1998-10-01), None
patent: WO 9852558 (1998-11-01), None
patent: WO 9852559 (1998-11-01), None
patent: WO 9852941 (1998-11-01), None
patent: WO 9857937 (1998-12-01), None
patent: WO 9857937 (1998-12-01), None
patent: WO 9857951 (1998-12-01), None
patent: WO 9923063 (1999-05-01), None
patent: WO 9924460 (1999-05-01), None
patent: WO 9932106 (1999-07-01), None
patent: WO 9932455 (1999-07-01), None
patent: WO 9956765 (1999-11-01), None
patent: WO 9963115 (1999-12-01), None
patent: WO 0051998 (2000-08-01), None
patent: WO 0055125 (2000-09-01), None
patent: WO 0055126 (2000-09-01), None
patent: US00/23584 (2001-01-01), None
patent: 950892 (1995-02-01), None
Ulf-Mueller-Ladner, et al; Cysteine Proteases in Arthritis and Inflammation; Perspectives in Drug Discovery & Design, vol. 6, pp. 87-98.*
Harold A. Chapman, et al; Emerging Roles for Cysteine Proteases in Human Biology; Annual Review Physiol. 1997, 59, 63-88.*
Hans-Hartwig Otto and Tanja Schirmeister; Cysteine Proteases and Their Inhibitors; Chem. Rev. 1997, 97, 133-171.*
Robert W. Marquis; Inhibition of Cysteine Proteases, Annual Reports in Medicinal Chemistry, Chapter 28, pp 309-320.
David Rasnick; Small Synthetic Inhibitors of Cysteine Proteases; Perspectives in Drug Discovery and Design, vol. 6, pp 47-63.
Richard J. Riese, et al; Cathepsin S Activity Regulates Antigen Presentation and Immunity; J. Clinicial Invest., The American Society for Clinical Investigation, Inc. vol. 101, No. 11, Jun. 1998, pp 2351-2363.
Harold A. Chapman, et al: Emerging Roles for Cysteine Proteases in Human Biology; Annual Review Physiol. 1997, 59, 63-88.
Ulf-Mueller-Ladner, et al; Cysteine Proteinases in Arthritis and Inflammation; Perspectives in Drug Discovery and Design, vol. 6, pp 87-98.
Galina K. Sukhova, et al; Expression of the Alastolytic Cathepsins S and K in Human Atheroma and Regulation of their Production in Smooth Muscle Cells; J. Clinical Invest. The American Society for Clinical Investigations, v
Bekkali Younes
Hickey Eugene R.
Liu Wei-min
Patel Usha R.
Spero Denice M.
Boehringer Ingelheim Pharmaceuticals Inc.
Bottino Anthony P.
Chang Ceila
Coppins Janet L
Witkowski Timothy X.
LandOfFree
Compounds useful as reversible inhibitors of cysteine proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds useful as reversible inhibitors of cysteine proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds useful as reversible inhibitors of cysteine proteases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3457004