Compounds useful as reversible inhibitors of cysteine proteases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S217030, C514S229200, C514S230500, C514S231200, C514S259500, C514S317000, C514S358000, C514S373000, C514S418000, C514S426000, C546S125000, C546S207000, C546S208000, C546S209000, C546S215000, C546S347000, C544S067000, C544S090000, C544S111000, C544S253000, C544S359000, C540S524000, C548S207000, C548S486000, C548S566000

Reexamination Certificate

active

06858623

ABSTRACT:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.

REFERENCES:
patent: 4734425 (1988-03-01), Nakane et al.
patent: 4749715 (1988-06-01), Hall
patent: 4797202 (1989-01-01), Klimpel et al.
patent: 4957932 (1990-09-01), Young et al.
patent: 4962117 (1990-10-01), Young et al.
patent: 5196291 (1993-03-01), Okada et al.
patent: 5218123 (1993-06-01), Horwell et al.
patent: 5250732 (1993-10-01), Kogan et al.
patent: 5328803 (1994-07-01), Fujikura et al.
patent: 5346907 (1994-09-01), Kerwin, Jr. et al.
patent: 5461176 (1995-10-01), Sun et al.
patent: 5504109 (1996-04-01), Seitz et al.
patent: 5514778 (1996-05-01), Hammond et al.
patent: 5633248 (1997-05-01), Kato et al.
patent: 5691368 (1997-11-01), Peet et al.
patent: 5710129 (1998-01-01), Lynch et al.
patent: 5744451 (1998-04-01), Allen et al.
patent: 5756528 (1998-05-01), Anthony et al.
patent: 5776718 (1998-07-01), Palmer et al.
patent: 5847135 (1998-12-01), Bemis et al.
patent: 5872122 (1999-02-01), Bovy et al.
patent: 5976858 (1999-11-01), Palmer et al.
patent: 3827727 (1990-02-01), None
patent: 4343528 (1993-12-01), None
patent: 4225487 (1994-02-01), None
patent: 4303145 (1994-08-01), None
patent: 4321897 (1995-01-01), None
patent: 19609955 (1997-09-01), None
patent: 19653647 (1998-06-01), None
patent: 0 115 472 (1984-08-01), None
patent: 0294668 (1988-12-01), None
patent: 0308885 (1989-03-01), None
patent: 0314060 (1989-05-01), None
patent: 0318083 (1989-05-01), None
patent: 0336356 (1989-10-01), None
patent: 0374098 (1990-06-01), None
patent: 0398072 (1990-11-01), None
patent: 0483667 (1992-05-01), None
patent: 0506008 (1992-09-01), None
patent: 0529737 (1993-03-01), None
patent: 0533244 (1993-03-01), None
patent: 0542463 (1993-05-01), None
patent: 0547699 (1993-06-01), None
patent: 587110 (1994-03-01), None
patent: 0 604 182 (1994-06-01), None
patent: 0611756 (1994-08-01), None
patent: 0611756 (1994-08-01), None
patent: 0644198 (1995-03-01), None
patent: 0649057 (1995-04-01), None
patent: 0 652 229 (1995-05-01), None
patent: 0672654 (1995-09-01), None
patent: 805147 (1997-11-01), None
patent: 810206 (1997-12-01), None
patent: 0 838 471 (1998-04-01), None
patent: 844248 (1998-05-01), None
patent: 844248 (1998-05-01), None
patent: 846464 (1998-06-01), None
patent: 846464 (1998-06-01), None
patent: 897908 (1999-02-01), None
patent: 2694006 (1994-01-01), None
patent: 662788 (1965-08-01), None
patent: 68010619 (1968-05-01), None
patent: 6358346 (1988-03-01), None
patent: 63301868 (1988-12-01), None
patent: 3002872 (1991-01-01), None
patent: 6003787 (1994-01-01), None
patent: 6051451 (1994-02-01), None
patent: 6145173 (1994-05-01), None
patent: 6293772 (1994-10-01), None
patent: 6340643 (1994-12-01), None
patent: 7-101959 (1995-04-01), None
patent: 7285931 (1995-10-01), None
patent: 8248579 (1996-09-01), None
patent: 11100373 (1999-04-01), None
patent: WO-8505031 (1985-11-01), None
patent: WO 8808717 (1988-11-01), None
patent: WO 8910920 (1989-11-01), None
patent: WO 9013561 (1990-11-01), None
patent: WO 9119733 (1991-12-01), None
patent: WO 9201675 (1992-02-01), None
patent: WO 9214465 (1992-09-01), None
patent: WO 9217453 (1992-10-01), None
patent: WO 9221361 (1992-12-01), None
patent: WO 9222570 (1992-12-01), None
patent: WO 9305444 (1993-03-01), None
patent: WO 9312075 (1993-06-01), None
patent: WO 9314069 (1993-07-01), None
patent: WO 9400435 (1994-01-01), None
patent: WO 9406757 (1994-03-01), None
patent: WO 9407841 (1994-04-01), None
patent: WO 9421657 (1994-09-01), None
patent: WO 9422911 (1994-10-01), None
patent: WO 9425432 (1994-10-01), None
patent: WO 9501344 (1995-01-01), None
patent: WO 9506029 (1995-03-01), None
patent: WO 9509838 (1995-04-01), None
patent: WO 9512611 (1995-05-01), None
patent: WO 9515749 (1995-06-01), None
patent: WO 9523222 (1995-08-01), None
patent: WO 9524382 (1995-09-01), None
patent: WO 9529899 (1995-11-01), None
patent: WO 9533728 (1995-12-01), None
patent: WO 9535308 (1995-12-01), None
patent: WO 9607638 (1996-03-01), None
patent: WO 9610559 (1996-04-01), None
patent: WO 9612499 (1996-05-01), None
patent: WO 9613502 (1996-05-01), None
patent: WO 9616940 (1996-06-01), None
patent: WO 9620725 (1996-07-01), None
patent: WO 9620949 (1996-07-01), None
patent: WO 9622970 (1996-08-01), None
patent: WO 9626194 (1996-08-01), None
patent: WO 9630353 (1996-10-01), None
patent: WO 9633168 (1996-10-01), None
patent: WO 9633170 (1996-10-01), None
patent: WO 9633211 (1996-10-01), None
patent: WO 9637499 (1996-11-01), None
patent: WO 9639137 (1996-12-01), None
patent: WO 9639384 (1996-12-01), None
patent: WO 9640647 (1996-12-01), None
patent: WO 9640737 (1996-12-01), None
patent: WO 9640741 (1996-12-01), None
patent: WO 9640742 (1996-12-01), None
patent: WO 9640744 (1996-12-01), None
patent: WO 9640751 (1996-12-01), None
patent: WO 9640752 (1996-12-01), None
patent: WO 9640753 (1996-12-01), None
patent: WO 9701275 (1997-01-01), None
patent: WO 9710219 (1997-03-01), None
patent: WO 9719908 (1997-06-01), None
patent: WO 9722618 (1997-06-01), None
patent: WO 9722619 (1997-06-01), None
patent: WO 9722621 (1997-06-01), None
patent: WO 9722621 (1997-06-01), None
patent: WO 9724343 (1997-07-01), None
patent: WO 9726246 (1997-07-01), None
patent: WO 9727200 (1997-07-01), None
patent: WO 9727220 (1997-07-01), None
patent: WO 9731016 (1997-08-01), None
patent: WO 9731016 (1997-08-01), None
patent: WO 9745016 (1997-12-01), None
patent: WO 9746518 (1997-12-01), None
patent: WO 9804278 (1998-02-01), None
patent: WO 9804518 (1998-02-01), None
patent: WO 9814450 (1998-04-01), None
patent: WO 9817679 (1998-04-01), None
patent: WO 9821199 (1998-05-01), None
patent: WO 9821199 (1998-05-01), None
patent: WO 9822433 (1998-05-01), None
patent: WO 9825617 (1998-06-01), None
patent: WO 9826654 (1998-06-01), None
patent: WO 9826654 (1998-06-01), None
patent: WO 9828269 (1998-07-01), None
patent: WO 9838177 (1998-09-01), None
patent: WO 9847863 (1998-10-01), None
patent: WO 9852558 (1998-11-01), None
patent: WO 9852559 (1998-11-01), None
patent: WO 9852941 (1998-11-01), None
patent: WO 9857937 (1998-12-01), None
patent: WO 9857937 (1998-12-01), None
patent: WO 9857951 (1998-12-01), None
patent: WO 9923063 (1999-05-01), None
patent: WO 9924460 (1999-05-01), None
patent: WO 9932106 (1999-07-01), None
patent: WO 9932455 (1999-07-01), None
patent: WO 9956765 (1999-11-01), None
patent: WO 9963115 (1999-12-01), None
patent: WO 0051998 (2000-08-01), None
patent: WO 0055125 (2000-09-01), None
patent: WO 0055126 (2000-09-01), None
patent: US00/23584 (2001-01-01), None
patent: 950892 (1995-02-01), None
Ulf-Mueller-Ladner, et al; Cysteine Proteases in Arthritis and Inflammation; Perspectives in Drug Discovery & Design, vol. 6, pp. 87-98.*
Harold A. Chapman, et al; Emerging Roles for Cysteine Proteases in Human Biology; Annual Review Physiol. 1997, 59, 63-88.*
Hans-Hartwig Otto and Tanja Schirmeister; Cysteine Proteases and Their Inhibitors; Chem. Rev. 1997, 97, 133-171.*
Robert W. Marquis; Inhibition of Cysteine Proteases, Annual Reports in Medicinal Chemistry, Chapter 28, pp 309-320.
David Rasnick; Small Synthetic Inhibitors of Cysteine Proteases; Perspectives in Drug Discovery and Design, vol. 6, pp 47-63.
Richard J. Riese, et al; Cathepsin S Activity Regulates Antigen Presentation and Immunity; J. Clinicial Invest., The American Society for Clinical Investigation, Inc. vol. 101, No. 11, Jun. 1998, pp 2351-2363.
Harold A. Chapman, et al: Emerging Roles for Cysteine Proteases in Human Biology; Annual Review Physiol. 1997, 59, 63-88.
Ulf-Mueller-Ladner, et al; Cysteine Proteinases in Arthritis and Inflammation; Perspectives in Drug Discovery and Design, vol. 6, pp 87-98.
Galina K. Sukhova, et al; Expression of the Alastolytic Cathepsins S and K in Human Atheroma and Regulation of their Production in Smooth Muscle Cells; J. Clinical Invest. The American Society for Clinical Investigations, v

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds useful as reversible inhibitors of cysteine proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds useful as reversible inhibitors of cysteine proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds useful as reversible inhibitors of cysteine proteases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3457004

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.