Compounds useful as phosphotyrosine mimics

Details Compounds useful as phosphotyrosine mimics Compounds useful as phosphotyrosine mimics

1999-12-07

2000-12-05

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514427, 514506, 514553, 514708, 548557, 548560, 548561, 548565, 560 19, 560 37, 560 55, 560 76, 562443, A61K 3140, A61K 31215, A61K 31185, C07C22904

Patent

active

061567841

ABSTRACT:
Disclosed are compositions containing compounds of the formula (I) below wherein A,B,C,G,Q and R are defined herein. The compounds are useful as phosphotyrosine mimics that, when incorporated into an appropriate molecular structure, inhibit the binding of tyrosine kinase-dependent regulatory proteins to their native phosphotyrosine-containing ligands or receptors. Also disclosed are methods for preparing the compounds of the formula (I). ##STR1##

REFERENCES:
patent: 5200546 (1993-04-01), Burke, Jr. et al.
patent: 5580979 (1996-12-01), Bachovchin
patent: 5891912 (1999-04-01), Kawashima et al.
Songyang, Zhou et al; SH2 Domains Recognize Specific Phosphopeptide Sequences, Cell. vol. 72, 767-773, Mar. 12, 1993.
Gilmer, T. et al; Peptide Inhibitors of src SH3-SH2 Phosphoprotein Interactions, The Journal of Biological Chemistry vol. 269, No. 50 Issue of Dec. 16, pp. 31711-31719.
Ye, Bin et al; L-0-(2-Malonyl)tyrosine: a New Phosphotyrosyl Mimetic for the Preparation of Src Homology 2 Domain Inhibitory Peptides, J. Med. Chem. 1995, 38, 4270-4275.
Burke, Terrence R. Jr. et al; Conformationally Constrained Phosphotyrosyl Mimetics Designed as Monomeric Src Homology 2 Domain Inhibitors, J. Med. Chem. 1995, 38, 1386-1396.
Wange, Ronald J. et al; F.sub.2 (Pmp(.sub.2 -TAM .zeta..sub.3 a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling.
Shahripour, A.. et al; Design, Synthesis and Structure Activity Studies of Peptidomimetic Ligands Targeting the pp60 src SH2 Domain, Parke-Davis, 221.sup.th ACS National Meeting Mar. 1996, Poster #194.
Para, K.S. et al; Design of Novel Peptidomimetic Ligands Targeting the pp60srcSH2 Domain: Transposed Sidechain and Rigid Scaffold Modifications, Parke-Davis, 211.sup.th ACS National Meeting Mar. 1996, Poster #195.
Jian Min Fu; Design and Synthesis of a Pyridone-Based Phosphotyrosine Mimetic, XP-002101974, Bioorganic & Medicinal Chemistry Letters 8, (1998), 2813-2816.
Zhu-Jun Yao, et al; Potent Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands J. of Med, Chem., vol. 32, No. 1, 1999, pp. 25-35, XP002138438.
Lai J.H. et al; "The Design, Synthesis and Activity of Pentape ptide PP60C-SRC Inhibitors Containing L-Phosphotyrosine Mimics", J. of Peptide Research, DD. Munksgaard International Publishers, Copenhagen, vol. 51, No. 4., Apr. 1, 1998 (Apr. 1, 1998) pp. 271-181, XP00736419, SSN1307-002X.
International Search Report for International Application No. PCT/US 99/27757.
Caplus 128:32126, abstract RN#'s 199526-77-7 and 199526-79-9, Nov. 1997.
Caplus 124:176907, Int. J. Pept. Protein Res. 1995 vol. 46 (6) pp. 535-546.
USpatfull 1999: 43656; RN #'s 179177-31-2, May 1996.

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