Compounds useful as motilin agonists and method

Details Compounds useful as motilin agonists and method Compounds useful as motilin agonists and method

2007-08-28

2007-08-28

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S230000, C544S236000

Reexamination Certificate

active

10940240

ABSTRACT:
Compounds are provided which are useful in treating disorders of gastrointestinal motility and which have the structureor a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomers thereof,wherein R1and R2are the same or different and are independently selected from hydrogen, alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl;Z is selected from —CON(R4)R4a, —CO2R4, —SO2N(R4)R4a, —SO2R4, CN, andR4and R4aare the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl or R4and R4acan be joined together to form a heterocycle.R4bis selected from hydrogen, halogen, hydroxyl, CN, OCF3, CF3, CONH2, SONH2, SO2CH3, NHCOCH3or NHCO2CH3; andQ is a substituted bicyclic heterocycle.A method for using such compounds for treating disorders of gastrointestinal motility is also provided.

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