Compounds useful as A 3 adenosine receptor agonists

Details Compounds useful as A 3 adenosine receptor agonists Compounds useful as A 3 adenosine receptor agonists

2004-07-26

2008-08-19

Crane, L. E. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S027230, C536S027620

Reexamination Certificate

active

07414036

ABSTRACT:
Adenosine analogue-type A3 receptor agonists having the formulawhereinD is N or CH;E is O;X1is a group of the formula —CR20R2 1-CYCLE, whereR20and R21are the same or different and are H, F or CH3;CYCLE iswhere G is N, CH, CF, CCH3or CCF3,M is H,Y is —O— or N═, andZ is —N═ when Y is O, or is O when Y is —N═;R5is H, CH3, I, Br, Cl, CF3, OH or NH2; andR8is —NR9R10, —CHR9R10or —N═CR9R10, where R9and R10are the same and are C1-C4alkyl, C1-C4alkenyl or C1-C4alkoxyalkylX2is mono-N— or di-N,N—(C1-C4)alkylaminocarbonyl, mono-N—or di-N,N—(C3-C5)cycloalkyl-aminocarbonyl or N-(C1-C4)alkyl-N-(C3-C5)cycloalkylamino-carbonyl;X3is OH or NH2;X4is OH;X5is H , halogen, (C1-C10)alkyl , (C2-C10)alkenyl , (C2-C10)alkynyl , or either of the latter two groups where terminally substituted by an aryl or heteroaryl group and, when having a terminal methyl group, optionally further terminally substituted by hydroxyl. The compounds may be used alone or with a pharmaceutically acceptable carrier or diluent to stimulate adenosine A3receptors.

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