Compounds used to treat alcoholism

Details Compounds used to treat alcoholism Compounds used to treat alcoholism

2006-04-11

2006-04-11

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S448000, C564S454000, C564S462000, C514S659000

Reexamination Certificate

active

07026514

ABSTRACT:
N,N′-bis(3-aminopropyl)cyclohexane-1,4-diamine, of formula (I), is a new compound that is prepared by hydrogenation with Raney nickel catalyst of N,N′-bis(2-cyanoethyl)-cyclohexane-1,4-diamine, the latter being prepared by reaction between 1,4-cyclohexanediamine and acrylonitrile. The oral administration to genetically alcoholic rats (from the strain UChB of the University of Chile) of the tetrametanesulfonate monohydrate of (I) causes a significant reduction in the alcohol consumption. The activity lasts for some time after the treatment period. Besides, there is a virtually null disulfiram-like adverse effect, what constitutes an advantage over the unpleasant use of some anti-alcoholism agents, such as calcium cyanamide or disulfiram itself. Therefore, the compounds of the invention are useful for the preparation of medicaments for the therapeutic and/or prophylactic treatment of alcoholism in mammals, including human beings

REFERENCES:
patent: 5534553 (1996-07-01), Hoerrmann
patent: 5962533 (1999-10-01), Bergeron
patent: 6399662 (2002-06-01), Bergeron
Klenke et al., J. Org. Chem. 2001, 66(7), p. 2480-2483.
Protective Groups in Organic Synthesis, 3rded., editors, Theodora W. Greene and Peter G. M. Wuts, 1999, John Wiley & Sons, Inc., New York, pp. 492-495, 518 (e-book).
Jerry March,Advanced Organic Chemistry, Jhon Wiley & Sons, Wiley Interscience, 4thEdition, ISBN 0-471-60180-2, pp. 918-919, reaction (Jun. 27, 1992).

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