Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2006-04-18
2006-04-18
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S235000, C544S237000, C544S335000, C544S336000, C544S353000, C546S146000, C546S174000, C546S334000, C548S180000, C548S204000, C548S205000, C548S214000, C548S236000, C548S247000, C548S335500, C548S375100, C548S494000, C548S561000, C549S058000, C549S074000, C549S076000, C549S469000, C549S492000, C549S494000
Reexamination Certificate
active
07030239
ABSTRACT:
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII)useful in treating Alzheimer's disease and other similar diseases.
REFERENCES:
patent: 4224179 (1980-09-01), Schneider
patent: 4231877 (1980-11-01), Yamauchi et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4247411 (1981-01-01), Vanlerberghe et al.
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4636491 (1987-01-01), Bock et al.
patent: 4665193 (1987-05-01), Ryono et al.
patent: 4668770 (1987-05-01), Boger et al.
patent: 4673567 (1987-06-01), Jizomoto
patent: 4676980 (1987-06-01), Segal et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4749792 (1988-06-01), Natarajan et al.
patent: 4753788 (1988-06-01), Gamble
patent: 4814270 (1989-03-01), Piran
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4870009 (1989-09-01), Evans et al.
patent: 4880781 (1989-11-01), Hester, Jr. et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 5010182 (1991-04-01), Brake et al.
patent: 5142056 (1992-08-01), Kempe et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5162538 (1992-11-01), Voges et al.
patent: 5175281 (1992-12-01), McCall et al.
patent: 5250565 (1993-10-01), Brooks et al.
patent: 5354866 (1994-10-01), Kempf et al.
patent: 5364934 (1994-11-01), Drayna et al.
patent: 5374652 (1994-12-01), Buzzetti et al.
patent: 5376542 (1994-12-01), Schlegal
patent: 5387742 (1995-02-01), Cordell
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5462067 (1995-10-01), Shapiro
patent: 5475138 (1995-12-01), Pal et al.
patent: 5481011 (1996-01-01), Chen et al.
patent: 5482947 (1996-01-01), Talley et al.
patent: 5498728 (1996-03-01), Sohda et al.
patent: 5502061 (1996-03-01), Hui et al.
patent: 5502187 (1996-03-01), Ayer et al.
patent: 5508294 (1996-04-01), Vazquez et al.
patent: 5510349 (1996-04-01), Talley et al.
patent: 5510388 (1996-04-01), Vazquez et al.
patent: 5516784 (1996-05-01), Bennett et al.
patent: 5521219 (1996-05-01), Vazquez et al.
patent: 5545640 (1996-08-01), Beaulieu et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5602169 (1997-02-01), Hewawasam et al.
patent: 5602175 (1997-02-01), Talley et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5610190 (1997-03-01), Talley et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5625031 (1997-04-01), Webster et al.
patent: 5631405 (1997-05-01), Pal et al.
patent: 5639769 (1997-06-01), Vazquez et al.
patent: 5648511 (1997-07-01), Ng et al.
patent: 5663200 (1997-09-01), Bold et al.
patent: 5703129 (1997-12-01), Felsenstein et al.
patent: 5708004 (1998-01-01), Talley et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5733882 (1998-03-01), Carr et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5753652 (1998-05-01), Fassler et al.
patent: 5760064 (1998-06-01), Vazquez et al.
patent: 5760076 (1998-06-01), Vazquez et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5807870 (1998-09-01), Anderson et al.
patent: 5807891 (1998-09-01), Bold et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5827891 (1998-10-01), Dressman et al.
patent: 5830897 (1998-11-01), Vazquez et al.
patent: 5831117 (1998-11-01), Ng et al.
patent: 5847169 (1998-12-01), Nummy et al.
patent: 5849911 (1998-12-01), Fassler et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5854211 (1998-12-01), Johansen et al.
patent: 5863902 (1999-01-01), Munoz et al.
patent: 5866684 (1999-02-01), Attwood et al.
patent: 5872101 (1999-02-01), Munoz et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5886046 (1999-03-01), Hirschmann et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5935967 (1999-08-01), Hausheer et al.
patent: 5942400 (1999-08-01), Anderson et al.
patent: 5962419 (1999-10-01), McDonald et al.
patent: 5965588 (1999-10-01), Vazquez et al.
patent: 6001813 (1999-12-01), Gyorkos et al.
patent: 6013658 (2000-01-01), Lau et al.
patent: 6022872 (2000-02-01), Vazquez et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 6051684 (2000-04-01), McDonald et al.
patent: 6060476 (2000-05-01), Vazquez et al.
patent: 6150344 (2000-11-01), Carroll et al.
patent: 6153652 (2000-11-01), Wu et al.
patent: 6191166 (2001-02-01), Audia et al.
patent: 6221670 (2001-04-01), Cordell et al.
patent: 6291678 (2001-09-01), Berryman et al.
patent: 2253835 (1997-12-01), None
patent: 3610593 (1987-10-01), None
patent: 3721855 (1988-09-01), None
patent: 40 03 575 (1991-08-01), None
patent: 0 036776 (1981-09-01), None
patent: 0 073 657 (1983-03-01), None
patent: 0 117 058 (1984-08-01), None
patent: 0 117 060 (1984-08-01), None
patent: 0 173 441 (1986-05-01), None
patent: 0 209 897 (1987-01-01), None
patent: 0 212 903 (1987-03-01), None
patent: 0 264 106 (1988-04-01), None
patent: 0 274 259 (1988-07-01), None
patent: 0 320 205 (1989-06-01), None
patent: 0 337 714 (1989-10-01), None
patent: 0 362 179 (1990-04-01), None
patent: 0 372 537 (1990-06-01), None
patent: 0437 729 (1991-07-01), None
patent: 0 609 625 (1994-08-01), None
patent: 0 652 009 (1995-05-01), None
patent: 2 203 740 (1988-10-01), None
patent: 2 211 504 (1989-07-01), None
patent: 7-126286 (1998-05-01), None
patent: WO 87/02986 (1987-05-01), None
patent: WO 87/04349 (1987-07-01), None
patent: WO 87/05330 (1987-09-01), None
patent: WO 8900161 (1989-01-01), None
patent: WO 89/01488 (1989-02-01), None
patent: WO 89/05859 (1989-06-01), None
patent: WO 90/13646 (1990-11-01), None
patent: WO 91/00360 (1991-01-01), None
patent: WO 92/00750 (1992-01-01), None
patent: WO 92/17490 (1992-10-01), None
patent: WO 92/20373 (1992-11-01), None
patent: WO 93/02057 (1993-02-01), None
patent: WO 93/08829 (1993-05-01), None
patent: WO 93/17003 (1993-09-01), None
patent: WO 94/04492 (1994-03-01), None
patent: WO 94/15956 (1994-07-01), None
patent: WO 95/06030 (1995-03-01), None
patent: WO 96/19483 (1996-06-01), None
patent: WO 96/35414 (1996-11-01), None
patent: WO 97/30072 (1997-08-01), None
patent: WO 98/22597 (1998-05-01), None
patent: WO 98/29401 (1998-07-01), None
patent: WO 98/33795 (1998-08-01), None
patent: WO 98/38167 (1998-09-01), None
patent: WO 98/50342 (1998-11-01), None
patent: WO 99/41266 (1999-08-01), None
patent: WO 99/54293 (1999-10-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 00/56335 (2000-09-01), None
patent: WO 00/61748 (2000-10-01), None
patent: WO 00/69262 (2000-11-01), None
patent: WO 00/77030 (2000-12-01), None
patent: WO 01/00663 (2001-01-01), None
patent: WO 01/00665 (2001-01-01), None
patent: WO 01/10387 (2001-02-01), None
patent: WO 01/19797 (2001-03-01), None
patent: WO 01/29563 (2001-04-01), None
patent: WO 01/23533 (2001-05-01), None
patent: WO 01/51659 (2001-07-01), None
Alterman et al.,J. Med. Chem, 1998, 41, 3782-3792. Design and Synthesis of New Potent C2-Symmetri HIV-1 Protease Inhibitors. Use of L-Mannaric Acid as a Peptidomimetic Scaffold.
Amblard et al.,J. Med. Chem., 1999, 42:20, pp. 4193-4201. Synthesis and Characterization for Bradykinin B2 Receptor Agonists Containing Constrained Dipeptide Mimics.
Arrowsmith et al.,Tetrahedron Letters, 28:45, pp. 5569-5572. Amino-Alcohol Dipeptide Analogues: A Simple Synthesis of a Versatile Isostere for the Development of Proteinase Inhibitors.
Askin et al.,The Journal of Organic Chemistry, 1992, 57:10, pp. 2771-2773. Highly Disastrous Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease.
Balicki et al.,Synth. Comm., 1993, 23(22), pp. 3149-3155. Mild and Efficient Conversion of Nitriles to Amides with Basic Urea-Hydrogen Peroxide Adduct.
Barton,Protective Groups in Organic Chemistry, 1976, Chpt. 2, pp. 43-93. Protection of N-H Bonds and NR3.
Basu et al.,Tetrahedron Letters, 1998, 39, pp. 3005-3006. Efficient Transformation of Nitrile into Amide Under Mild Condition.
Bennett et al.,Synlett, 1993, 9, pp. 703-704. The Synthe
Fang Lawrence Y.
Gailunas Andrea
Hom Roy
John Varghese
Mamo Shumeye S.
Elan Pharmaceuticals Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
Tucker Zachary C.
Wilson James O.
LandOfFree
Compounds to treat Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds to treat Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds to treat Alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3531243