Compounds that release nitric oxide at controlled rates upon...

Details Compounds that release nitric oxide at controlled rates upon... Compounds that release nitric oxide at controlled rates upon...

2006-10-17

2006-10-17

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Azoxy doai

C534S551000, C534S552000, C534S556000, C534S567000, C534S568000, C423S405000

Reexamination Certificate

active

07122529

ABSTRACT:
Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted diazeniumdiolates. Also provided are methods of preparing these novel compounds in high chemical yields as well as methods of using these compounds.

REFERENCES:
patent: 5366997 (1994-11-01), Keefer et al.
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patent: 5683668 (1997-11-01), Hrabie et al.
patent: 5814666 (1998-09-01), Green et al.
patent: WO 94/27957 (1994-12-01), None
A. Srinivasan et al; Chemistry of the Diazeniumdiolates. 3. Photoreactivity; J. Am. Chem. Soc., 2001, No. 123, pp. 5464-5472.
J. Saavedra et al; Targeting Nitric Oxide (NO) Delivery in Vivo. Design of a Liver-Selective NO Donor . . . ; J. Med. Chem., 1997, No. 40; pp. 1947-1954.
P. Ruane et al; Controlled Photochemical Release of Nitric Oxide from O2-Benzyl-Substituted Diazenlumdiolates; J. Am. Chem. Soc. 2002, No. 124, pp. 9806-9811.

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