Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-02-25
2004-08-31
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S467000
Reexamination Certificate
active
06784205
ABSTRACT:
BACKGROUND
Diabetes mellitus is a major risk factor for potentially debilitating diseases such as cardiovascular disease and stroke, and is the leading cause of blindness, renal failure and lower limb amputations in adults. Type 2 or noninsulin-dependent diabetes mellitus accounts for over ninety percent of all diabetes cases. Although current treatments for type 2 diabetes result in lower levels of blood sugar, side effects include weight gain, hyperglycemia, edema, and liver toxicity. Obesity, a condition that is often strongly correlated with diabetes further complicates treatment options. In particular, obesity further exacerbates the insulin resistance that is a hallmark of diabetes so that current treatments for diabetes typically lose their efficacy after a few years. As a result, a need exists for new and improved methods for treating diabetes and/or its associated complications.
REFERENCES:
You-Ten, Kong E. et al., “Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase-deficient Mice”, J. Exp. Journ., vol. 186, No. 5, Aug. 1997, pp. 683-693.
Tonks, Nicholas K. et al., “Combinatorial Control of the Specificity of Protein Tyrosine Phosphatases”, Current Opinion in Cell Biology 2001, 13:182-195.
Barr Kenneth
Fahr Bruce
Hansen Stig
Wiesmann Christian
Heller Ehrman White & McAuliffe LLP
Owens Amelia A.
Sunesis Pharmaceuticals, Inc.
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