Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-04-15
2000-08-01
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514444, 514467, 514512, 514557, 548252, 549 60, 549 74, 549 76, 549 78, 549452, 549550, 560 17, 560 22, 562431, 564163, A61K 3119, A61K 3141, C07D31750, C07D40912
Patent
active
060967730
ABSTRACT:
A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.
REFERENCES:
patent: 4372974 (1983-02-01), Fish et al.
patent: 5192746 (1993-03-01), Lobl et al.
patent: 5510332 (1996-04-01), Kogan et al.
patent: 5654301 (1997-08-01), Kohn et al.
Biediger Ronald J.
Grabbe Vanessa O.
Kassir Jamal
Keller Karin M.
Kogan, deceased Timothy P.
McKane Joseph K.
Solola Taofiq A.
Texas Biotechnology Corporation, Inc.
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