Compounds that inhibit T cell proliferation and methods using th

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 14, 514 15, 514 16, 514 17, 514 18, 530326, 530327, 530328, 530329, 530330, 530331, A61K 3800, A61K 3804, C07K 500, C07K 700

Patent

active

059588829

ABSTRACT:
Compounds which display a surface similar to the surface presented by one of five distinct lateral domains of CD4 are disclosed. Methods of treating individuals suspected of suffering from or susceptible to conditions characterized by an undesired immune response comprising administering to the individual at least one compound which mimics a portion of the lateral surface of the CD4 glycoprotein are disclosed.

REFERENCES:
patent: 5589458 (1996-12-01), Jameson et al.
Bank et al., "Perturbation of the T4 Molecule Transmits a Negative Signal to T Cells", J. Exp. Med., 1985, 162, 1294-1303.
Barber et al., "The CD4 and CD8 Antigens are Coupled to a Protein-Tyrosine Kinase (p56.sup.lck) that Phosphorylates the CD3 Complex".
Biddison et al., "Possible Involvement of the OKT4 Molecule in T Cell Recognition of Class II HLA Antigens", J. Exp. Med., 1982, 156, 1065-1071.
Carr et al., J. Biol. Chem., 1989, 264(35), 21286-21295.
Dianzani et al., "Molecular Associations on the T Cell Surface Correlate with Immunological Memory", Eur. J. Immunol., 1990, 20, 2249-2257.
Fleury et al., "Mutational Analysis of the Interaction Between CD4 and Class II MHC: Class II Antigens Contact CD4 on a Surface Opposite the gp120-Binding Site", Cell, 1991, 66, 1037-1049.
Gay et al., "Functional Interaction Between Human T-cell Protein CD4 and the Major Histocompatibility Complex HLA-DR Antigen", Nature, 1987, 328, 626-629.
Glaichenhaus et al., "Requirement for Association of p56.sup.lck with CD4 in Antigen-Specific Signal Transduction in T Cells", Cell, 1991, 64, 511-520.
Harris et al., Euro. J. Bioch., 1990, 194, 611-620.
Hussey et al., "A Soluble CD4 Protein Selectively Inhibits HIV Replication and Syncytium Formation", Nature, 1988, 331, 78-81.
Jameson et al., "Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein", Science, 1988, 240, 1335-1339.
Jameson, B.A., "Modelling in Peptide Design", Nature, 1989, 341, 465.
Janeway, C.A., "The Co-Receptor Function of CD4", Sem. Immunol., 1991, 3, 153-160.
Janeway et al., "Cross-Linking and Conformational Change in T-Cell Receptors: Role In Activation and In Repertoire Selection", CSH Symp. Quant. Biol., 1989, LIV, 657-666.
Korngold et al., "Variable Capacity of L3T4.sup.+ T Cells to Cause Lethal Graft-Versus-Host Disease Across Minor Histocompatibility Barriers in Mice", J. Exp. Med., 1987, 165, 1552-1564.
Korngold et al., "Acute Experimental Allergic Encephalomyelitis in Radiation Bone Marrow Chimeras Between High and Low Susceptible Strains of Mice", Immunogens, 1986, 24, 309-315.
Kumar et al., "A Two-Dimensional Nuclear Overhauser Enhancement (2D NOE) Experiment for the Elucidation of Complete Proton Cross-Relaxation Networks in Biological Macromolecules", Biochem. Biophys. Res. Commun., 1980, 95, 1.
Ledbetter et al., "Signal Transduction Through CD4 Receptors: Stimulatory vs. Inhibitory Activity is Regulated by CD4 Proximity to the CD3/T Cell Receptor", Eur. J. Immunol., 1988, 18, 525-532.
Maddon et al., "The Isolation and Nucleotide Sequence of a cDNA Encoding the T Cell Surface Protein T4: A New Member of the Immunoglobulin Gene Family", Cell, 1985, 42, 93-104.
Maddon et al., "The T4 Gene Encodes the AIDS Virus Receptor and is Expressed in the Immune System and the Brain", Cell, 1986, 47, 333-348.
Matsui et al., "Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors", Science, 1991, 254, 1788-1791.
Matthews et al., "Studies on the Leukocyte-Common Antigen: Structure, Function, and Evolutionary Conservation", CSH Symp. Quant. Biol., 1989, LIV, 675-682.
McDonnell et al., "Direct Involvement of the CDR3-Like Domain of CD4 in Helper Cell Activation", J. Immunol., 1992, 149, 1626.
Merrifield, R.B., "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 1963, 85, 2149-2154.
Mittler et al., "T-Cell Receptor-CD4 Physical Association in a Murine T-Cell Hybridoma: Induction by Antigen Receptor Ligation", PNAS USA, 1989, 86, 8531-8535.
Mittler et al., "Physical Associations Between CD45 and CD4 or CD8 Occur as Late Activation Events in Antigen Receptor-Stimulated Human T Cells", J. Immunol., 1991, 147, 3434-3440.
Mustelin et al., "Rapid Activation of the T-Cell Tyrosine Protein Kinase pp56.sup.lck by the CD45 Phosphotyrosine Phosphatase", PNAS USA, 1989, 86, 6302-6306.
Ostergaard et al., "Coclustering CD45 with CD4 or CD8 Alters the Phosphorylation and Kinase Activity of p56.sup.lck ", J. Exp. Med., 1990, 172, 347-350.
Parnes, "Molecular Biology and Function of CD4 and CD8", Adv. Immunol., 1989, 44, 265-311.
Raine et al., "On the Immunopathology of Plaque Development and Repair in Multiple Sclerosis", J. Neuroimmunol., 1988, 20, 189-201.
Rivas et al., "CD4 Molecules are Associated with the Antigen Receptor Complex on Activated But Not Resting T Cells", J. Immunol., 1988, 140, 2912-2918.
Shaw et al., "Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56.sup.lck Tyrosine Protein Kinase", Mol. Cell. Biol., 1990, 10, 1853-1862.
Tite et al., "The Role of L3T4 in T Cell Activation: L3T4 May be Both an Ia-Binding Protein and a Receptor that Transduces a Negative Signal", J. Mol. Cell. Immunol., 1986, 2, 179-189.
Turner et al., "Interaction of the Unique N-Terminal Region of Tyrosine Kinase p56.sup.lck with Cytoplasmic Domains of CD4 and CD8 is Mediated by Cysteine Motifs", Cell, 1990, 60, 755-765.
European Patent Office Supplementary European Search Report dated Jun. 12, 1997, 4 pages.
McDonnell et al., "Rational design of a peptide analog of the L3T4 CDR3-like region", Immunomethods, 1992, 1, 33-39.
Ohki et al., "Monoclonal antibodies to a CD4 peptide derivative which includes the region corresponding to an immunoglobulin CDR3: Evidence of the involvement of Pre-CDR3-Related Region in HIV-1 and Host Cell Interaction", Mol. Immunol., 1992, 29(11), 1391-1400.
Deibler et al., "Isolation of Tryptic Peptides of Myelin Basic Protein by Reversed-Phase High-Performance Liquid Chromatography", J. Chrom., 1985, 326, 433-442.
Mazerolles et al., "Immunosuppressive Properties of Synthetic Peptides Derived from CD4 and HLA-DR Antigens", Cell, 1988, 55, 497-504.
Zagury et al., "Critical sites: a semantic approach to protein sequences. Application to the HIV-1 envelope molecule", Biomed & Pharmacother, 1992, 46, 343-351.
Carr et al., J. Biol. Chem., 1989, 264(35) pp. 21286-21295.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds that inhibit T cell proliferation and methods using th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds that inhibit T cell proliferation and methods using th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds that inhibit T cell proliferation and methods using th will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-703225

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.