Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-15
2005-03-15
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S394000, C548S224000, C548S304700
Reexamination Certificate
active
06867227
ABSTRACT:
Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.
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L. Wang et al., Specific molecular recognition of mixed nucleic acid sequences: an aAromatic dication thatbinds in the DNA minor groove as a dimer,Procs. Natl. Acad. Sci. 97, 12-16 (2000).
Boykin David W.
Tidwell Richard R.
Wilson W. David
Georgia State University Research Foundation, Inc.
Jenkins & Wilson & Taylor, P.A.
Solola Taofiq
The University of North Carolina at Chapel Hill
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