Compounds that bind to digitalis receptor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 41, C07J 500, A61K 31705

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active

051440172

ABSTRACT:
Novel steroid compounds which are glycoside derivatives of 14.beta.-hydroxypregnane and 17.alpha.-acetoxy-6.alpha.-methylpregnane are described. The compounds have increased receptor potency when compared to their aglycone and beneficial renal effects.

REFERENCES:
patent: 3740390 (1973-06-01), Heider et al.
patent: 3752803 (1973-08-01), Eberlein et al.
patent: 3857832 (1974-12-01), Hartenstein et al.
patent: 3907776 (1975-09-01), Eberlein et al.
patent: 3949074 (1976-04-01), Eberlein et al.
patent: 4031212 (1977-06-01), Losel et al.
patent: 4088757 (1978-05-01), Peterson
patent: 4242332 (1980-12-01), Albrecht et al.
patent: 4380624 (1983-04-01), Wiesner et al.
patent: 4895836 (1990-01-01), Chiodini et al.
Brown et al; Naunyn-Schmiedeberg's Archives of Pharmacology 332:98-102 (1986).
Lucas et al; J. Am. Chem. Soc. 82:5688-5693 (1960).
Chow et al; Br. J. Pharmac. 67:345-352 (1979).
Kim et al; Molecular Pharmacology 18:402-405 (1980).
LaBella et al; Can. J. Physiol. Pharmacol. 62:1057-1064 (1984).
LaBella et al; Nature 278:571-573 (Apr. 5, 1979).
Brown et al; Arz Neim.-Forsch./Drug Res. 31(II), No. 7: 1059-1064 (1981).
LaBella et al; Fed. Proc. (FASEB) 44(12):2806-2811 (1985).
"Endogenous Digitalis: Current Status and Progesterone Derivatives as Candidates" by LaBella et al Proc. West. Pharmacol. Soc. 30:365 to 371 (1987).
"Progesterone Derivatives that Bind to the Digitalis Receptor: Synthesis of 14-Hydroxyprogesterone" by Templeton et al, J. Med. Chem. 1987, 30, 1502 to 1505.
"14-Hydroxyprogesterone Binds to the Digitalis Receptor, Inhibits the Sodium Pump and Enhances Cardiac Contractility" by Bose et al, Br. J. Pharmacy, 93:453 to 461 Feb. 1988.
"Structure-Activity-Relationships of Progesterone Derivatives that Bind to the Digitalis Receptor: Modifications in A and B Rings" by Templeton et al, Steroid, May-Jun. 1987 Ed. (pub. Apr. 1988).
"Digitalis-like Pregnanes Cardiac and Renal Effects of a Glycoside of 14.beta.-Hydroxyprogesterone" by Templeton et al, Can. J. Physical. Pharmacol., 66, 1420 to 1428 (1988).
"Cardiac Glycoside-like Structure and Function of 5.beta., 14.beta.-Pregnanes" by Templeton et al, J. Med. Chem., 32, 1977 to 1981 (1989).
Weiland et al in J. Enz. Inhib. 2:31 to 36, 1987.
The Pharmacologist, 29:135, (1987), Halpryn et al.

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