Compounds that associate on the intermolecular level and...

Details Compounds that associate on the intermolecular level and... Compounds that associate on the intermolecular level and...

2007-11-13

2007-11-13

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S013800, C514S014800, C514S015800, C514S016700, C514S017400, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000, C530S330000

Reexamination Certificate

active

10019902

ABSTRACT:
Compound of the general formula (I)in-line-formulae description="In-line Formulae" end="lead"?X(B)m  (I)in-line-formulae description="In-line Formulae" end="tail"?whereinX is an m-valent unit andB are identical or different and denote K-R, whereinK is a bond or is A1—(A2—A3)k-sp, whereinA1is (CH2)tY(CH2)u, whereinY is >C═O, >NH, —O—, —S— or a bond,t is an integer from 0 to 6 andu is an integer from 0 to 6,A2is —NHCO—, —CONH—, —OCONH— or SCONH—, or is —CO—,A3is (CH2)r, O(CH2)r, NH(CH2)r, S(CH2)ror —(CHQ)—, whereinr is an integer from 1 to 6 andQ is a substituted or unsubstituted alkyl or aryl group,sp is a divalent spacer or a bond, andk is an integer from 5 to 100, andR is hydrogen; a ligand suitable for specific bonding to a receptor; a marker molecule; or a catalytically active group; andm is at least 2,with the proviso that(1) in the compound at least one R is not hydrogen,(2) there are at least two K that are not a bond, and(3) X, B and m are so selected that an intermolecular association of the K in liquid phase by the formation of hydrogen bonds is possible, with formation of aggregates that present on the surface a plurality of R that are not hydrogen, and(4) the molar mass of the fragment X(K)mis less than 20,000.

REFERENCES:
patent: 5243035 (1993-09-01), Nakabayashi et al.
patent: 6676946 (2004-01-01), Bay et al.
patent: 0601417 (1994-06-01), None
patent: 0601417 (1994-06-01), None
patent: 747063 (1996-12-01), None
patent: WO 93/17033 (1993-09-01), None
patent: WO 94/06467 (1994-03-01), None
patent: WO 96/26933 (1996-09-01), None
patent: WO 97/31006 (1997-08-01), None
patent: WO 98/142015 (1998-04-01), None
patent: WO 00/55149 (2000-09-01), None
Tuzikov, A. B., et al “Polyglycine II nanosheets” ChemBioChem (2003) vol. 4, pp. 147-154.
Mammen, M. et al “Polyvalent interactions in biological systems . . . ” Angew. Chem. Int. Ed. (1998) vol. 37, pp. 2754-2794.
CAS abstract document No. 121:109622. (1994).
Watowich, S. et al “Crystal structures of influenza virus hemagglutinin . . . ” Structure (1994) vol. 2, pp. 719-731.
CAS abstract document No. 122:99869. (1994).
International Search Report for PCT/AU00/00165 dated Apr. 5, 2000.
Meindl et al., “Inhibition of Neuraminidase Activity by Derivatives of 2-Deoxy-2,3-dehydro-N-acetyl-Neuraminic Acid,”Virology58: 457-463 (1974).
Meindl et al., “Synthese und Eigen schaften von 2-Deoxy-2,3-dehydroneuraminsaure sowie neuer N-Acylderivative,”Monatschefie fur Chemie104: 402-414 (1973).
Choi et al. (1997) “Generation and in Situ Evaluation of Libraries of Poly (acrylic acid) Presenting Sialosides as Side Chains as Polyvalent Inhibitors of Influenza-Mediated Hemagglutination”J. Am. Chem. Soc.119:4103-4111.
Chow et al. (1998) “The Synthesis and Properties of Novel Functional Dendritic Molecules”Tetrahedron54:8543-8660.
Feofanov et al. (1997) “Study of Sialylated Neoglycoconjugates by Surface-Enhanced Raman Scattering Spectroscopy” 23:910-918 (Abstract in English Only).
Gambaryan et al. (1997) “Specification of Receptor-Binding Phenotypes of Influenza Virus Isolates from Different Hosts Using Synthetic Sialylglycopolymers: Non-Egg-Adapted Human H 1 and H3 Influenza A and Influenza B Viruses Share a Common High Binding Affinity for 6'-Sialyl(N-acetyllactosamine)”Virology232:345-350.
Kretzschmar et al. (1995) “Oligosaccharide Recognition by Selectins: Synthesis and Biological Activity of Multivalent Sialyl Lewis-X Ligans”Tetrahedron51:13015-13030.
Nishimura et al. (1994) “Chemoenzymic Preparation of a Glycoconjugate Polymer Having A Sialylogiosaccharide: Neu5Acα(2→3)Galβ(l→4)GlcNAc”Biochemical and Biophysical Research Communications199:249-254.
Reuter et al. (1999) “Inhibition of Viral Adhesion and Infection by Sialic-Acid-Conjugated Dendritic Polymers”Bioconjugate Chem.10:271-278.
Reuter et al. (1998) “Sialic Acid Conjugated Dendritic Polymers Inhibit Influenza Virus Binding to Target Cells in a Strutural and Virus Strain-Specific Manner”Antimicrobial Chemotherapy98:51 (abstract only).
Roy et al. (1993) “Solid-phase Synthesis of Dendritic Sialoside Inhibitors of Influenza A Virus Haemagglutinin”J. Chem. Soc. Chem. Comm.24:1869-1872.
Unverzagt et al. (1994) “Chemical and enzymatic synthesis of multivalent sialoglycopeptides”Carbohydr. Res.251:285-301.
Yamada et al. (Dec. 1997) “High performance polymer supports for enzyme-assisted synthesis of glycoconjugates”Carbohydr. Res.305:443-461.
Wu et al. (2000) “Synthesis of a Polymeric 4-N-linked Sialoside which Inhibits Virus Hemagglutinin”Bioorganic&Medicinal Chemistry Letter10:341-343.
Zanini et al. (1996) “Novel Dendritic α-Sialosides: Synthesis of Glycodendrimers Based on a 3, 3 ′-Iminobis(propylamine) Core”J. Org. Chem.61:7348-7354.
International Search Report for PCT Application No. PCT/EP00/06139, mailed Oct. 9, 2001.
Guedj, C. et al. (1995) “Vesicles and other supramolecular systems from biocompatible synthetic glycolipids with hydrocarbon and/or fluorocarbon chains” Abstract inChemical Abstracts,122: 1099.
Kopecek, Jindrich et al. (1995) “Drug-delivery polymers and pharmaceutical compositions employing them” Czech Republic Patent No. CZ 278,551, Abstract inChemical Abstracts, 122:600.
Lio, Raul Gonzalez et al. (1999) “Chemoenzymatic Synthesis of Spacer-Linked Oligosaccharides for the Preparation of Neoglycoproteins.”Carbohydrate Research,317:180-190.
Sabesan, Subramaniam et al. (1992) Cluster Sialoside Inhibitors for Influenza Virus: Synthesis, NMR, and Biological Studies.Journal of the American Chemical Society,114:8363-8375.
Shimizu, Toshimi. (1999) “Noncovalent synthesis and structural properties of supramolecular polymer architectures from bola-form amphiphiles” Abstract inChemical Abstracts,130(20): 293.
Zanini, Diana et al. (1998) Practical Synthesis of Starburst PAMAM α-Thiosialodendrimers for Probing Multivalent Carbohydrate-Lectin Binding Properties.Journal of Organic Chemistry,63: 3486-3491.

Affiliated with

Also associated with

Rating

Compounds that associate on the intermolecular level and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds that associate on the intermolecular level and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds that associate on the intermolecular level and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3858562