Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2011-08-30
2011-08-30
Hui, San-Ming (Department: 1628)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
08008492
ABSTRACT:
Compounds of formula (I), where R1and R3are H or (C1-C4)-alkyl; R2is H or a C-radical derived from one of the known ring systems with 1-4 rings; X1is a (C1-C6)-alkyl biradical derived from a linear or branched carbon chain; and X2is —NH—, —NH—(CH2)1-3—COO—, —NH—(CH2)1-3—S—, or —NH—CO—(CH2)1-3—S—, are useful as blood-brain barrier shuttles (BBB). BBB shuttle-cargo constructs, the cargo being a substance susceptible to form an amide or an ester or a disulfide bound with X2and being unable to cross the blood-brain barrier by itself, are useful as medicaments.
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Giralt Lledó Ernest
Teixidó Turà Meritxell
Berenbaum Weinshienk PC
Hui San-ming
Kalan K
Scull Peter B.
Zarek Paul
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