Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-04-18
2006-04-18
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S106000, C544S170000, C544S171000, C544S224000, C544S242000, C544S336000, C544S358000, C546S302000, C514S237500, C514S252100, C514S252120
Reexamination Certificate
active
07030111
ABSTRACT:
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.
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Kawabe Takumi
Kobayashi Hidetaka
Canbas Co., Ltd.
Pillsbury Winthrop Shaw & Pittman LLP
Shameem Golam M. M.
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