Compounds possessing neuronal activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S330000, C514S333000, C546S193000, C546S194000, C546S227000, C546S256000

Reexamination Certificate

active

07109215

ABSTRACT:
The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that utilize them can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma.

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US District Court of Oregon dismissal (2003).
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J.M. Defauw et al., “Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogs that are Highly Selective for Protein Kinase C over Protein Kinase A”,J. Med. Chem., 39(26), pp. 5215-5227 (1996).
T. Fukuyama et al., “2,4-Dinitrobenzenesulfonamides: A Simple and Practical Method for the Preparation of a Variety of Secondary Amines and Diamines”,Tetrahedron Lett., 38(33), pp. 5831-5834 (1997).
Oregon Health & Science University's First Amended Complaint, filed Dec. 7, 2001 in the United States District Court, District of Oregon.
Vertex Pharmaceuticals Incorporated's Answer, filed Dec. 21, 2001 in the United States District Court, District of Oregon.

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