Compounds of use in the treatment of epilepsy, seizure, and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S646000, C514S658000, C564S330000, C564S430000, C564S434000

Reexamination Certificate

active

10845143

ABSTRACT:
The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically effective amount of a therapeutic compound having the following formula (I):Embodiments include administering an effective amount of 4,4′-thiodianiline, 4,4′-diaminobenzophenone, 4,4′-methylenedianiline, 4,4′-diaminodiphenyl ether, or (3-aminophenyl)-(4-aminophenyl) amine, an analog, or a pharmaceutically accepted salt or complex thereof to a mammal in need of treatment or prevention of epilepsy, seizure, or other electroconvulsive disorder.

REFERENCES:
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patent: 4816485 (1989-03-01), Satzinger et al.
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patent: 4933368 (1990-06-01), Satzinger et al.
Database CAPLUS on STN, Acc. No. 1939:17619, McLeod, Biochemical Journal (1938), 32, p. 1770-4 (abstract).
Database CAPLUS on STN, Acc. No. 1992:99253, Hamada et al, Epilepsy Research (1991), 10(2-3), p. 93-102 (abstract).
Database CAPLUS on STN, Acc. No. 1948:10534, Barry et al., “Antitubercular activity of diphenyl ethers and related compounds.” Nature (1947), 160, p. 800-1 (abstract).

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