Compounds of the saframycin-ecteinascidin series, uses, and...

Details Compounds of the saframycin-ecteinascidin series, uses, and... Compounds of the saframycin-ecteinascidin series, uses, and...

2005-08-30

2005-08-30

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

06936714

ABSTRACT:
Compounds of the saframycin-ecteinascidin series with cytotoxic properties having the following general formula, their uses and synthesis, are disclosed:wherein R1and R4is H, a C1to C4alkyl group, or an acyl group;wherein R2is an ether, ester, amide, or a phthalimide group;wherein R3is ═O, OH, an ether group, an acyl group such as OC(O)Me, OC(O)Bn and OC(O)Et, or a sulfide group; wherein R5is H, halogen, OH, an ether group, an acyl group, or an amide group; wherein R6is ═O, OH, OCH3, CN, or an acyloxy group;wherein R7, is ═O, OH, halogen, an ether group, or an acyl group; wherein R8and R9are independently H, CH3, OCH3, OC2H5, CF3, halogen such as Br and F, or R8and R9are joined together as a methylenedioxy group, or other five or six membered ring; wherein R10and R11are independently CH3, OCH3, OC2H5, SCH3, or SC2H5; wherein R12is H, a C1to C4alkyl group, or an acyl group; and wherein the chiral center marked * has the R or the S configuration.

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