Compounds of the plasminogen type and method for obtaining such

Details Compounds of the plasminogen type and method for obtaining such Compounds of the plasminogen type and method for obtaining such

1974-12-17

1978-09-19

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3550

Patent

active

041155513

ABSTRACT:
The placental pulps notably of human origin are separated from the placental blood, which is removed, and the pulps are macerated in a solution at a pH comprised between 5 and 10, e.g. isotonic NaCl solution, preferably at neutral pH, in the presence of an amino-acid inhibitor of plasminogen activation, at a molar concentration comprised between about 0.001 and 0.1 M, preferably of the order of 0.035 M. The pulps are removed and the solution containing the compounds of the plasminogen type is recovered. Preferred inhibitors are L-lysine, epsilon aminocaproic acid, and trans-4 aminomethyl cyclohexane carboxylic acid.

REFERENCES:
patent: 3234106 (1966-02-01), Hink et al.
The Journal of Biological Chemistry, vol. 246, No. 14, issue of Jul. 25, 1971, pp. 4641-4647.
Science, vol. 170, No. 3959, Nov. 13, 1970, pp. 1095 & 1096.
Chemical Abstracts, vol. 80, p. 148, which includes references to Aichi Ika Daigaku Igakukai Zasshi, (1973), 1(4), pp. 247-262.
Rickli et al., Biochim. Biophys. Acta, 250 (1971), pp. 447-451.
Rickli et al., Biochim. Biophys. Acta, 295 (1973), pp. 381-384.
Wallen et al., Biochim. Biophys. Acta., 221 (1970), pp. 20-30.
Claeys et al., Biochimica et Biophysica Acta. 342 (1974), pp. 351-359.

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