Compounds of ergolene and ergoline structure and method for the

Details Compounds of ergolene and ergoline structure and method for the Compounds of ergolene and ergoline structure and method for the

1977-03-02

1978-08-22

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424274, C07D45702

Patent

active

041088557

ABSTRACT:
The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain.
The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.

REFERENCES:
patent: 4005089 (1977-01-01), Mago et al.

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