Compounds, methods of screening, and in vitro and in vivo...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S006120, C435S007100, C435S007210

Reexamination Certificate

active

06902885

ABSTRACT:
Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; Compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; Methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; Methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; Pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.

REFERENCES:
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patent: WO 96/30404 (1996-10-01), None
patent: WO 97/12632 (1997-04-01), None
patent: WO 97/15326 (1997-05-01), None
Kouzarides et al.,Virology, 165:151-164 (1988).
Al-Barazi and Colberg-Poley,J. Virol. 70:7198-7208 (1996).
Tenney and Colberg-Poley,Virology182:199-210 (1991).
Colberg-Poley et al.,J. Virol. 66:95-105 (1992).
Colberg-Poley et al.,Intervirology39:350-360 (1996).
Zhu et al,J. of Virology, 69(12):7960-7970 (1995).

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