Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-21
2006-11-21
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S559000, C549S384000
Reexamination Certificate
active
07138428
ABSTRACT:
Disclosed herein are an acetone-extracted product obtained from gamboge resin and compounds further purified from said acetone-extracted product, including a new compound called formoxanthone A. The acetone-extracted product and the further purified compounds have been demonstrated to have activities in inhibiting the growth of tumor/cancer cells. Also disclosed are the processes for obtaining said further purified compounds, and the uses of the acetone-extracted product and the further purified compounds in the preparation of pharmaceutical composition for inhibiting the growth of tumor/cancer cells.
REFERENCES:
patent: 6462041 (2002-10-01), Cai et al.
patent: 0 428 815 (1991-05-01), None
Zhi, Influence of a different processes on bactericidal and tumoricidal effects of gamboges, (1996) PMID:9388932.
Ito, Xanthones as inhibitors of Epstein-Barr virus activation, Cancer Letters 132 (1998) 113-117.
“Betulinic Acid,” ACS:Betulinic Acid, http://www.cancer.org/docroot/ETO/content/ETO—5—3x—Betulinic—Acid.asp?sitearea=..., Jul. 18, 2003.
“Pharmacology fo Betulinic Acid,” Cyberbotanica: Betulinic Acid, http://biotech.icmb.utexas.edu/botany/betul.html, Jul. 18, 2003.
Koichi Yamashita et al., “Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils,” Clinica Chimica Acta 325 (2002), pp. 91-96.
Darrick S. H. L. Kim et al., “Synthesis of Betulinic Acid Derivatives with Activity Against Human Melanoma,” Bioorganic & Medicinal Chemistry Letters 8 (1998), pp. 1707-1712.
Simone Fulda et al., “Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid,” The Journal of Biological Chemistry, vol. 273, No. 51, Issue of Dec. 18, 1998, pp. 33942-33948.
G. I. Saitl et al., “Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent,” Melanoma Research, vol. 11, 2001, pp. 99-104.
Philippe Bernard et al., “Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A2inhibitors,” Phytochemistry 58 (2001) pp. 865-874.
Valentina Zuco et al., “Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells,” Cancer Letters 175 (2002), pp. 17-25.
Arnab Roy Chowdhury et al., “Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives,” www.MEDSCIMONIT.com, 2002, pp. BR254-260.
Chen Chiu-Ming
Lee Sen-Bin
Owens Amelia A.
Pillsbury Winthrop Shaw & Pittman LLP
Taiwan Sunpan Biotechnology Development Company, Ltd.
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