Compounds having selective hydrolytic potentials

Details Compounds having selective hydrolytic potentials Compounds having selective hydrolytic potentials

2006-05-30

2006-05-30

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S263210, C514S263220, C514S263350, C514S263360, C544S267000, C544S269000, C544S271000

Reexamination Certificate

active

07053096

ABSTRACT:
Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.

REFERENCES:
patent: 286041 (1988-10-01), None
patent: 17684 (1993-09-01), None
Allevi et al., Tetrahdron Letters, vol. 33, No. 33, pp. 4831-4834, “A Short and Simple Synthesis of the Antitumor Agent Etoposide”, 1992.
Bundgaard, et al., J. Med. Chem., vol. 32, No. 12, pp. 2503-2507, “A Novel Solution-Stable, Water-Soluble Prodrug Type for Drugs Containing a Hydroxyl or an NH-Acidic Group”, 1989.
Hussain et al., J. Pharma, Sci., vol. 76, No. 5, pp. 356-358, “Improvement of the Oral Bioavailability of Naltrexone in Dogs: A Prodrug Approach”, 1987.
Riley et al., J. Chem. Education, vol. 65, No. 11, pp. 947-953, “The Prodrug Concept and New Drug Design and Development”, 1988.

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