Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-03-23
2009-12-29
Chu, Yong (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S442000, C562S452000, C562S488000, C562S492000, C549S332000, C549S398000, C549S405000, C549S408000, C549S429000, C548S146000, C548S206000, C548S215000, C548S240000, C546S329000
Reexamination Certificate
active
07638648
ABSTRACT:
Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
REFERENCES:
patent: 4326055 (1982-04-01), Loeliger
patent: 5349105 (1994-09-01), Chandraratna
patent: 5648503 (1997-07-01), Vuligonda et al.
patent: 5723666 (1998-03-01), Vuligonda et al.
patent: 5952345 (1999-09-01), Klein et al.
patent: 6252090 (2001-06-01), Vasudevan et al.
patent: 6291677 (2001-09-01), Vasudevan et al.
patent: 6303785 (2001-10-01), Vasudevan et al.
patent: 6313107 (2001-11-01), Vasudevan et al.
patent: 6369225 (2002-04-01), Vasudevan et al.
patent: 6369261 (2002-04-01), Johnson et al.
patent: 6380256 (2002-04-01), Vasudevan et al.
patent: 7226951 (2007-06-01), Vasudevan et al.
patent: 2002/0160986 (2002-10-01), Vasudevan et al.
patent: 2002/0183285 (2002-12-01), Vasudevan et al.
patent: 1 277 227 (1972-06-01), None
patent: 58 121242 (1983-07-01), None
patent: WO 02/18361 (2002-03-01), None
Asao, N., et al., “π-π Chelation Controlled Chemoselective Conjugate Addition of Lithium Dimethylcuprate,”Tetrahedron Letters, 44(9): 1803-1805 (2003).
Barlaam, B., et al., “New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors,”J. Med. Chem., 42(23): 4890-4908 (1999).
Bligh, E., et al., “A Rapid Method of Total Lipid Extraction and Purification,”Canadian Journal of Biochemistry, 37(8): 911-917 (1959).
Bouchain, G., et al., “Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deaceylase Inhibitors,”J. Med. Chem., 46(5): 820-830 (2003).
Castro, C., et al., “Copper (I) Substitutions. Scope and Mechanism of Cuprous Acetylide Substitutions,”Journal of the American Chemical Society, 91(23): 6464-6470 (1969).
Costa, A., et al., “P2-Et-Mediated Deprotonation ofortho-Halobenzyl Sulfones: Synthetic Applications as Zwitterionic Synthons,”Synlett, 12: 1881-1884 (2001).
De Porre, et al., “Second Generation Retinoic Acid Metabolism Blocking Agent (Ramba) R116010: Dose Finding in Healthy Male Volunteers,”University of Leuven, Belgium, pp. 30.
Floyd, M., et al., “Cyclic Analog of Ethacrynic Acid,”Journal of Pharmaceutical Sciences, 59(6): 869-870 (1970).
Hamon, D., et al., “Enantioselective Syntheses of 2-Arylpropanoic Acid Non-steroidal Anti-inflammatory Drugs and Related Compounds,”Tetrahedron, 51(46): 12645-12660 (1995).
Hanzlik, R., et al., “Cyclopropylamines as Suicide Substrates for Cytochromes P450RAI,”Journal of Medicinal Chemistry, 22(7): 759-761 (1997).
Hanzlik, R., et al., “Suicidal Inactivation of Cytochrome P450RAI by Cyclopropylamines-Evidence for Cation-Radical Intermediates,”J. Am. Chem. Soc., 104(107): 2048-2052 (1982).
Kang, S., et al., “Liarozole Inhibits Human Epidermal Retinoid Acid 4-Hydroxylase Activity and Differentially Augments Human Skin Responses to Retinoic Acid and Retinol In Vivo,”The Journal of Investigative Dermatology, 107(2): 183-187 (1996).
Konek, F., et al., “Über einige neue Derivate der Paracumar- und Vanillinsäure,”Chemische Berichte, 51: 855-865 (1918).
Kuijpers, A., et al., “The Effects of Oral Liarozole on Epidermal Proliferation and Differentiation in Severe Plaque Psoriasis are Comparable With Those of Acitretin,”British Journal of Dermatology, 139: 380-389 (1998).
Kwon, B., et al., “Synthesis and Biological Activity of Cinnamaldehydes as Angiogenesis Inhibitors,”Bioorganic&Medicinal Chemistry Letters, 7(19): 2473-2476 (1997).
Lopez, F., et al., “N-Methylanilines From Benzylic Azides,”Tetrahedron Letters, 40(11): 2071-2074 (1999).
Nakao, K., et al., “Qualitative Structure-Activity Analyses of Novel Hydroxyphenylurea Derivatives as Antioxidants,”Bioorganic&Medicinal Chemistry, 6(6): 849-868 (1998).
Ortiz de Montellano, P., “Topics in Biology—The Inactivation of Cytochrome P450,” InAnnual Reports in Medicinal Chemistry, Denis M. Bailey, eds. (Academic Press, Inc.) vol. 19: 201-211 (1984).
Sengupta, S., et al., “Iodoarenediazonium Salts: A New Class of Aromatic Substrates for Differential Palladium Catalyzed Reactions,”Tetrahedron Letters, 39(7): 715-718 (1998).
Teng, M., et al., “Identification of a Retinoic Acid Receptor α Subtype Specific Agonist,”Journal of Medicinal Chemistry, 39(16): 3035-3038 (1996).
Van Wauwe, J., et al., “Liarozole, an Inhibitor of Retinoic Acid Metabolism, Exerts Retinoid-Mimetic Effects in Vivo,”The Journal of Pharmacology and Experimental Therapeutics, 261(2): 773-779 (1992).
Van Wauwe, J., et al., “Ketoconazole Inhibits the in Vitro and in Vivo Metabolism of All-Trans-Retinoic Acid,”The Journal of Pharmacology and Experimental Therapeutics, 245(2): 718-722 (1998).
White, J., et al., “cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450,”The Journal of Biological Chemistry, 272(30): 18538-18541 (1997).
White, J., et al., “Identification of the Human Cytochrome P450, P450RAI-2, Which is Predominantly Expressed in the Adult Cerebellum and is Responsible for alltransRetinoic Acid Metabolism,”Prac. Natl. Acad. Sci. USA, 97(12) 6403-6408 (2000).
Xin, Z., et al., “A Practical and Efficient Intramolecular Michael Addition of Ureas to α, β-unsaturated esters,”Tetrahedron Letters, 41(8): 1147-1150 (2000).
Beard Richard
Bhat Smita
Chandraratna Roshantha A.
Li Ling
Liu Xiaoxia
Allergan Inc.
Chu Yong
Hamilton Brook Smith & Reynolds P.C.
LandOfFree
Compounds having selective cytochrome P450RAI-1 or selective... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds having selective cytochrome P450RAI-1 or selective..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having selective cytochrome P450RAI-1 or selective... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4052625