Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2011-01-25
2011-01-25
Havlin, Robert (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C514S570000
Reexamination Certificate
active
07875745
ABSTRACT:
The present invention relates to a compound represented by formula (I):(wherein the symbols in formula were described in the description), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention binds to and is antagonistic to an LPA receptor (particularly, EDG-2), it is useful for prevention and/or treatment of urinary system disease (prostatic hypertrophy or neurogenic bladder dysfunction disease, spinal cord neoplasm, nucleous hernia, spinal canal stenosis, diseases caused by diabetes, occlusion disease of lower urinary tract, inflammatory disease of lower urinary tract, and polyuria), carcinoma-associated disease, proliferative disease, inflammation system disease, immune system disease, disease by secretory dysfunction, brain-related disease and/or chronic disease.
REFERENCES:
patent: 2006/0148830 (2006-07-01), Terakado et al.
patent: 2007/0149595 (2007-06-01), Tanaka et al.
patent: 62-164661 (1987-07-01), None
patent: 1-299283 (1989-12-01), None
patent: 10-287651 (1998-10-01), None
patent: 2001-226362 (2001-08-01), None
patent: 2002-293764 (2002-10-01), None
patent: WO 02/062389 (2002-08-01), None
patent: WO 2004/002530 (2004-01-01), None
patent: WO 2004/031118 (2004-04-01), None
Contos et al., (Mol Pharmacol 58:1188-1196, 2000).
Kubinyi (3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, vol. 2-3, Springer, 1998, 800 pages).
Bryn et al., Pharm. Res., v. 12, n. 7, p. 945-54, 1995.
Heasley et al. (Bioorganic & Medicinal Chemistry Letters 14 (2004) 2735-2740).
International Search Report for PCT/JP04/019456 dated Apr. 12, 2005.
Dorwald F. Zaragoza, “Side Reactions in Organic Synthesis”, 2005, p. IX of Preface, Wiley: VCH, Weinheim.
Nakade Shinji
Takaoka Yoshikazu
Tanaka Motoyuki
Havlin Robert
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
LandOfFree
Compounds having lysophosphatidic acid receptor antagonism... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds having lysophosphatidic acid receptor antagonism..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having lysophosphatidic acid receptor antagonism... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2694175