Compounds having improved fluorescence in fluorescence polarizat

Details Compounds having improved fluorescence in fluorescence polarizat Compounds having improved fluorescence in fluorescence polarizat

1992-11-10

1994-05-24

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549224, 549225, 549226, 549227, C07D49310

Patent

active

053150155

ABSTRACT:
Compounds of the formula ##STR1## wherein F is a fluorescing compound; Y is --NH-- or a single covalent bond; Z is a straight or branched alkylene chain of 2 to 10 carbon atoms which is substituted by at least one hydrophilic group; Q is oxygen or sulfur; and X is a ligand-analog, the ligand-analog capable of being recognized by an antibody specific to the corresponding ligand. These compounds have improved properties in fluorescence polarization immunoassays by possessing either a better intensity and/or a larger span.

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Dandliker, et al., Immunochemistry, 10, pp. 219-227 (1973).
Fairclough & Cantor, Methods in Enzymology, 48, pp. 347-379 (1978).

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