Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-07-19
1992-07-07
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514654, 514655, 548518, 562899, C07C40312, C07D31902, A61K 3140, A61K 31095
Patent
active
051283654
ABSTRACT:
The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H.sub.2 O.sub.2 and other peroxides. The present invention also provides methods and pharmaceutical compositions of the compound.
REFERENCES:
patent: 4730053 (1988-03-01), Dereu
patent: 4910313 (1990-03-01), Welter
Epp. O., Ladenstein, R., Wendel, A. (1983), Eur. J. Biochem., 133:51-69 (Exhibit A).
Reich, N. J., Jasperse, C. P. (1987) J. Am. Chem. Soc., 109:5549-5551 (Exhibit B).
Klein, K. P., Hauser, C. R. J. (1967) Org. Chem., 32:1479-1483 (Exhibit C).
Gould, E. S., McCullough, J. D., (1951) J. Am. Chem Soc., 73:1109-1112 (Exhibit D).
Spector Abraham
Wilson Stephen R.
Zucker Paul A.
Gerstl Robert
New York University
The Trustees of Columbia University in the City of New York
White John P.
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