Compounds having GABA like activity, and use of same in tissue i

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546164, 546165, C07D21548, A61K 3147

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active

049525735

ABSTRACT:
Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.

REFERENCES:
patent: 3975530 (1976-08-01), Durant et al.
patent: 4375472 (1983-03-01), Durant et al.
patent: 4443432 (1984-04-01), Garabedian et al.
patent: 4550022 (1985-10-01), Garabedian et al.
Dikstein et al, Corneal Endothelial Pumping in the Presence of Insulin and GABA; Exp. Eve Res., vol. 31, pp. 239-241 (1980).
The Merch Index, pp. 746, 1342, 1343.

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