Compounds having effects on serotonin-related systems

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514213, 514278, 514323, 540543, 540586, 540593, 540597, 546 16, 546 17, 546101, 546140, 546143, 546177, 546187, 546195, 546201, C07D22700, C07D40112, A61K 31395, A61K 31445

Patent

active

057417890

ABSTRACT:
A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.

REFERENCES:
patent: 3929793 (1975-12-01), Popelak et al.
patent: 4146630 (1979-03-01), Kampe et al.
patent: 4244961 (1981-01-01), Kluge et al.
patent: 4288442 (1981-09-01), Friebe et al.
patent: 4304915 (1981-12-01), Berthold
patent: 4361562 (1982-11-01), Berthold
patent: 4460586 (1984-07-01), Berthold
patent: 4803203 (1989-02-01), Caprathe et al.
patent: 4849431 (1989-07-01), Sugimoto et al.
patent: 4935414 (1990-06-01), Stenzel et al.
patent: 5013761 (1991-05-01), Beedle et al.
Hall et al., Brain Research 745 (1997) 96-108.
Raymond et al., Am. M. Physiol., 1993, vol. 264, No. 1, part 2, pp. F9-F19.
Hoyer et al., Brain Researh 376 (1986) 85-86.
Sanchez et al., European J. Pharmacology, 315 (1996) 245-254.
De Vry et al., Drug Development Research vol. 30, No. 2, pp. 91-103 (1993).
Schreiber et al., Prog. Neuro-Psychopharmacol. & Biol. Psychiat. (1993), vol. 17, pp. 87-104.
Pitchot et al., Pharmacopsychiatry (1995), vol. 28 (supplement) pp. 91-92.
Coccaro et al., International Clinical Psychopharmacology, (1995), 10, 177-179.
Simpson et al., Proceedings of the BPS, 14-16 Jul. 1993.
Krystal, Journal of Clinical Psychiatrty, (1996), V. 57, S. 10, pp. 22-23.
Mutschler et al. "drug Actions, Basic Principles and Therapeutic Aspects", published 1995 by Medpharm Scientific Publishers (Stuttgart), pp. 309-312.
West, et al., Psychopharmacology, 104, 91-96 (1991).
Hilleman, et al., Arch. Intern. Med., 152, 350-352 (1992).
Artigas, TiPs, 14, 262 (1993).
Fuller, Life Sciences, 55, 163-167 (1994).
Jacobsen, J. Clin. Psychiatry, 52, 217-220 (1991).
Hjorth, J. Neurochem., 60, 776-779 (1993).
Artigas, et al., Arch. Gen. Psychiatry, 51, 248-251 (1994).
Hoey, et al., European J. of Pharm., 231, 477-480, (1993).
Marxer, et al., J. Org. Chem., 40, 1427-1433 (1975).
Parham, et al., J. Org. Chem., 41, 2628-2635 (1976).
Yamato, et al., J. Med. Chem., 24, 194-198 (1981).
Evans, et al., J. Med. Chem., 35, 3919-3927 (1992).
Efange, et al., J. Med. Chem., 37, 2574-2582 (1994).
Chambers, et al., J. Med. Chem., 35, 2033-2039 (1992).
Armah, et al., Br. J. Pharmacol., 96, 807-816 (1989).
Derwent Abstract, Japanese 2121-924-A.
Derwent Abstract, Japanese 2121-966-A.
Raina. Antihistominic Activity of Synthetic Quinoline Derivatives. Indian J. Med Res. (59) 614-26, (1971).
Bennur. 1-Substituted Alkylamino-3-(4-quinazolyhoxy)-2-Propanol . . . Revue Roumaine de Chimie, 20, 9-10, 1295-99 (1975).
Mehrotra. Substituted Quinoline as menoamine oxidase inhibitors and analyesies. Chem Abstracts 98:143248.
Faye et al. Principles of Medicinal Chemistry, 4th ed. Williams & Wilkins 1995 p. 199.
Mehrotra, et al., Indian J. Physiol. Pharmacol., 26(3), 253-7 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds having effects on serotonin-related systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds having effects on serotonin-related systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having effects on serotonin-related systems will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2057638

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.