Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-22
1999-06-15
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514253, 514316, 544364, 546187, 546201, A61K 31445, A61K 31495, C07D40114
Patent
active
059122560
ABSTRACT:
A series of 1-(4-indolyloxy)-3-(4-hydroxy-4-naphthylpiperidin-1-yl)propanes are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor, yet lack mutagenic potential as measured by assays of chromosomal aberration. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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patent: 5627196 (1997-05-01), Audia et al.
Rasmussen et al in "Recent Progress in Serotonin (5-HT)1A Receptor Modulators", Ann. Reports in Medicinal Chemistry. 30 pp. l-9, 1995.
Saxena, Pharmac. Ther. vol. 66, pp. 339-368, 1995.
Koch Daniel James
Rocco Vincent Patrick
Bernhardt Emily
Eli Lilly and Company
Lentz Nelsen L.
Palmberg Arleen
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