Compounds having antitumor and antibacterial properties

Details Compounds having antitumor and antibacterial properties Compounds having antitumor and antibacterial properties

1992-07-13

1994-01-25

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549392, A61K 31335, C07D31178

Patent

active

052816206

ABSTRACT:
The novel class of xanthenone-4-acetic acids represented by the general formula (I) ##STR1## where R.sub.1 represents up to two of the groups lower alkyl, halogen, CF.sub.3, CN, NO.sub.2, NH.sub.2, CH.sub.2 COOH, OR.sub.2, OH, NHCOR.sub.2, NHSO.sub.2 R.sub.2, SR.sub.2, SO.sub.2 R.sub.2, CH.sub.2 CONHR.sub.2 or NHR.sub.2 (where R.sub.2 is lower alkyl optionally substituted with hydroxy, amino or methoxy functions), at any of the positions 1-8 which are available, R.sub.1 may also represent the substitution of an aza (--N.dbd.) group for one or two of the methine (--CH.dbd.) groups in the carbocyclic rings and two of R.sub.1 on any two available adjacent positions may also represent the grouping --CH.dbd.CH--CH.dbd.CH-- to form an additional fused benzene ring;
and basic addition salts thereof, possess antitumour and antibacterial properties.

REFERENCES:
Nakanishi et al., Chem Abstr., 76: 126,784w (1972). (Abstract of Japan 7200425).
Nishino et al., Bull. Chem. Soc. Jpn., 56, 2847-48 (1983).
Nishino et al., ibid., 56, 474-480 (1983).

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