Compounds having antiprogestational and anti-estrogenic activiti

Details Compounds having antiprogestational and anti-estrogenic activiti Compounds having antiprogestational and anti-estrogenic activiti

1994-02-14

1998-03-31

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514168, 514191, 514170, 514182, A61K 31595, A61K 3156

Patent

active

057339023

ABSTRACT:
Agents, containing at least one compound having antiprogestational activity and at least one compound having anti-estrogenic activity, are suitable for the treatment of hormone-dependent tumors.

REFERENCES:
patent: 4656187 (1987-04-01), Black et al.
patent: 4670426 (1987-06-01), Zor et al.
patent: 4732904 (1988-03-01), Morgan
patent: 4760053 (1988-07-01), Labrie
patent: 4775660 (1988-10-01), Labrie
patent: 4775661 (1988-10-01), Labrie
patent: 4857519 (1989-08-01), Paris
Hissom et al., "Progestin Effects on Growth in the Human Breast Cancer Cell Line T-47D-. . . etc", Biochemical and Biophysical Research Communications, vol. 145, No. 2, 1987, Jun. 15, 1987 pp. 706-711.
Bardon, et al: Steroid Receptor-mediated Cyclotoxicity of an Antiestrogen and an Antprogestin in Breast Cancer Cells, Cancer Research, 47, 1441-1448 (1987).
CA : vol. 107 : 52276(s) (1987).
CA : vol. 107 : 17986(b) (1987).

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