Compounds having antiinflammatory activity, obtained by complexa

Details Compounds having antiinflammatory activity, obtained by complexa Compounds having antiinflammatory activity, obtained by complexa

1984-11-13

1986-07-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 46, 536103, A61K 3173

Patent

active

046031235

ABSTRACT:
New inclusion compounds of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide with .alpha., .beta. or .gamma. cyclodextrins, obtained by reaction of said cyclodextrins and said 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide in aqueous or water/organic solutions are described. The ratio between 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-1,1-dioxide and the cyclodextrins is comprised between 1:10 and 1:1; preferably, it is about 1:2.5.
The compounds of the invention possess high antiinflammatory and analgesic activities, together with a considerably reduced gastrolesive action.

REFERENCES:
patent: 3969338 (1976-08-01), Staron
patent: 4365061 (1982-12-01), Szejtle et al.
patent: 4380626 (1983-04-01), Szejtle et al.
patent: 4478995 (1984-10-01), Shinoda et al.

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