Compounds having anti-inflammatory and anti-viral activity, comp

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514425, 514426, 548952, 435 692, 562553, 562577, 562582, A01N 4336, C07D20510, C12P 2102, C07C20928

Patent

active

057055220

ABSTRACT:
A new family of compounds having anti-inflammatory, anti-viral, and brocho-dilating activity having the following linear and cyclic formulas: ##STR1## and compositions of these, which alone, and in combination with reverse transcriptase inhibitors thereby resulting in an additive or synergistic effect, are useful in inhibiting or suppressing viruses including those exhibiting retroviral replication, or in treating viruses including a retrovirus such as HIV in a human cell population and methods of using these compositions, compounds, and salts thereof.

REFERENCES:
patent: 4861759 (1989-08-01), Mitsuya et al.
patent: 5254539 (1993-10-01), Mitsuya et al.
patent: 5571839 (1996-11-01), Vila et al.
PCT/ISA/220 Notification of Transmittal of the International Search Report or Declaration dated Dec. 18, 1996.
International Search Report dated Dec. 10, 1996.
Blodgett, et al., "Specific Cleavage of Peptides Containing an Aspartic Acid (.beta.-hydroxamic Acid)", J. Am. Chem. Soc., 1985, 107, 4305-4313.
J. Org. Chem., vol., 42, No. 10, (1977), pp. 1750-1761, Miller et al., "The Chemistry of a Method for the Determination of Carboxyl-Terminal Residues in Peptide".
J. Am Chem. Soc. 1985, vol. 107, pp. 4305-4313 "Specific Cleavage of Peptides Containing an Aspartic Acid (.beta.-Hydroxamic Acid) Residue", Blodgett et al.
CDC (Center for Disease Control), MMWR, 30: 305-308.DC, (1981).
Barre-Sinoussi F. et al., Science, 220: 868-870 (1983).
Fauci AS., Science, 239, 617-622, (1988).
Fauci AS., Science, 262: 1011-1018. (1993).
Zack J.A. et al., Cell, 61, 213-222, (1990).
Bukrinsky M.I. et al,; Science, 254, 423-427, (1991).
Schnittman S M. et al., Science, 245, 305-308, (1989).
Fox CH. et al., J. Infect Dis; 164, 1051-1057, (1991).
Hirsch MS, et al., New Engl. J. Med. 328, 1686-1695, (1993).
Pauwels, R. et al., J. Virol. Methods, 20, 309-321 (1988).
Yarchoan et al., New Engl J. Med, 321, 726-738 (1989).
Chow et al., Nature, 361, 650-654 (1993).
Lori et al., Science, 266: 801-805 (1994).
McMillan R., et al, TIPS, Aug. 1992, vol. 13, pp. 323-330.
Merck Index 10, 8741, 8744, 8745, (1983).
M. Bodansky, A. Bodansky, The Practice of Peptide Synthesis, 125 (1984).
Vogel, Text-Book of Practical Organic Chemistry, 371, 375-377 and 840, (3rd. edition, 1957).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds having anti-inflammatory and anti-viral activity, comp does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds having anti-inflammatory and anti-viral activity, comp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having anti-inflammatory and anti-viral activity, comp will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2329474

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.