Compounds from biopolymers and effector substances which are lin

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...

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5303919, C12N 996, C07K 1644

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active

057732710

ABSTRACT:
Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof.
The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active easter group.

REFERENCES:
patent: 4868106 (1989-09-01), Ito et al.
Augustin et al., Journal f. prakt Chemie, vol. 327, No. 5, pp. 857-864 (1985).
Keller et al., "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides", Helvetica Chimica Acta--vol. 58, No. 2 (1975) pp. 531-541.
Rich et al., "Alkylating Derivatives of Amino Acids and Peptides. Synthesis Vasopressin-Stimulated Water Loss from Isolated Toad Bladder.", J. Med. Chem. 18 (1975) pp. 1004-1010.
Anderson et al., "The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis", J. Am. Chem. Soc. 86 (1964) pp. 1839-1842.
Ghose et al., "Preparation of Antibody-Linked Cytotoxic Agents", Methods in Enzymology, vol. 93 (1983) pp. 280-333.
Ishikawa et al., "Enzyme Labeling of Antibodies and Their Fragments for Enzyme Immunoassay and Immunohistochemical Staining", Journal of Immunoassay, vol. 4, No. 3 (1983) pp. 209-237.

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