Compounds from biopolymers and effector substances which are lin

Details Compounds from biopolymers and effector substances which are lin Compounds from biopolymers and effector substances which are lin

1995-06-07

1998-04-28

Ceperley, Mary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241831, 424809, G01N 33535, G01N 33563, A61K12100

Patent

active

057443157

ABSTRACT:
Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof. The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group.

REFERENCES:
patent: 4868106 (1989-09-01), Ito et al.
Keller et al., "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides", Helvetica Chimica Acta, 58(2):531-541 (1975).
Rich et al., "Alkylating Derivatives of Amino Acids and Peptides. Synthesis Vasopressin-Stimulated Water Loss from Isolated Toad Bladder", J. Med. Chem., 18:1004-1010 (1975).
Anderson et al., "The Use of Esters of N-hydroxysuccinimide in Peptide Synthesis", J. Am. Chem. Soc., 86:1839-1842 (1964).
Ghose et al., "Preparation of Antibody-Linked Cytotoxic Agents", Methods in Enzymology, 93:280-333 (1983).
Ishikawa et al., "Enzyme Labeling of Antibodies and Their Fragments for Enzyme Immunoassay and Immunohistochemical Staining", J. Immunoassay, 4(3):209-237 (1983).
Augustin et al., Journal f. prakt Chemie, vol. 327, No. 5, pp. 857-864 (1985).

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