Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-08-04
1998-12-15
Dentz, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 14, 5462837, 5462714, 5462717, 5462734, 546322, 546315, C07F 702
Patent
active
058499148
ABSTRACT:
This invention relates to a key intermediate in the synthesis of an endothelin antagonist and the synthesis of this key intermediate using an asymmetric conjugate addition reaction.
REFERENCES:
patent: 5017608 (1991-05-01), Ashwanden et al.
patent: 5389620 (1995-02-01), Ishikawa et al.
Alexakis, et al., "Diastereoselective Conjugate Addition With Acetals, Oxazolidines and Imidazolidines as Chiral Auxiliaries", Tetrahedron Letters, vol. 29(35), pp. 4411-4414, 1988.
Shinohara et. al., Bull. Chem. Soc. Japan, vol. 38, pp. 1,3, 1965.
Dolling Ulf H.
Frey Lisa F.
Tillyer Richard D.
Tschaen David M.
Camara Valerie J.
Daniel Mark R.
Dentz Bernard
Merck & Co. , Inc.
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