Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-09-22
1985-04-09
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
2601125R, A61K 3700, C07C10352
Patent
active
045101329
ABSTRACT:
A compound having the general formula ##STR1## in which Dab is diaminobutyric acid; A is either leucine, threonine, isoleucine or phenylalanine; B is either leucine or threonine; D is either D-leucine or D-phenylalanine; and C is a substituent selected from the group comprising --Dab--Thr, --Dab--Thr--Dab, --Dab, --Dab--Thr--Acyl and H, in which Thr is threonine, Acyl is a lower acyl group of 1 to 5 carbon atoms and Dab is as defined above. These compounds are useful in sensitizing Gram-negative bacteria to antibacterial agents and to the host defence mechanism complement when subjecting said Gram-negative bacteria to the action of said compounds. The invention also provides a pharmaceutical composition for use in sensitizing Gram-negative bacteria to antibacterial agents, complement or both, comprising a therapeutically effective amount of said compound in admixture with a pharmaceutically acceptable carrier. Polymyxin B nonapeptide having the formula: ##STR2## is produced by treating polymyxin B with ficin, papain or bromelin.
REFERENCES:
patent: 2695261 (1954-11-01), Ainsworth et al.
patent: 2759868 (1956-08-01), Bushby
patent: 4237045 (1980-12-01), Failli et al.
patent: 4252795 (1981-02-01), Failli et al.
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