Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2008-01-29
2008-01-29
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S585000, C514S594000, C564S023000, C564S026000, C564S044000, C564S047000
Reexamination Certificate
active
07323496
ABSTRACT:
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
REFERENCES:
patent: 2524827 (1950-10-01), Papa et al.
patent: 3275520 (1966-09-01), Strobel et al.
patent: 3609183 (1971-09-01), DeWald et al.
patent: 3683009 (1972-08-01), Middleton
patent: 4074057 (1978-02-01), Kawamatsu et al.
patent: 4217366 (1980-08-01), Kikumoto et al.
patent: 4271186 (1981-06-01), Forster et al.
patent: 4284637 (1981-08-01), Kikumoto et al.
patent: 4310534 (1982-01-01), Kikumoto et al.
patent: 4312855 (1982-01-01), Grand
patent: 4326055 (1982-04-01), Loeliger
patent: 4444779 (1984-04-01), Kawamatsu et al.
patent: 4716905 (1988-01-01), Schmued
patent: 4866086 (1989-09-01), Boyle et al.
patent: 4929635 (1990-05-01), Coquelet et al.
patent: 4940707 (1990-07-01), Klaus et al.
patent: 5087637 (1992-02-01), Janssen et al.
patent: 5162337 (1992-11-01), Elbrecht et al.
patent: 5171753 (1992-12-01), Munson, Jr. et al.
patent: 5189056 (1993-02-01), Orlando et al.
patent: 5246936 (1993-09-01), Treacy et al.
patent: 5250562 (1993-10-01), Klaus et al.
patent: 5314693 (1994-05-01), Suga
patent: 5378705 (1995-01-01), Klaus et al.
patent: 5391565 (1995-02-01), Hindley
patent: 5409953 (1995-04-01), Pettit et al.
patent: 5430062 (1995-07-01), Cushman et al.
patent: 5457226 (1995-10-01), Gygax
patent: 5494932 (1996-02-01), Cardin et al.
patent: 5521160 (1996-05-01), Chucholowski et al.
patent: 5525632 (1996-06-01), Obsumi et al.
patent: 5532129 (1996-07-01), Heller
patent: 5559151 (1996-09-01), Adorante et al.
patent: 5565191 (1996-10-01), Raspanti
patent: 5565322 (1996-10-01), Heller
patent: 5569786 (1996-10-01), Pettit et al.
patent: 5583128 (1996-12-01), Bhatnagar
patent: 5587150 (1996-12-01), Deflandre et al.
patent: 5589506 (1996-12-01), Hashimoto et al.
patent: 5672625 (1997-09-01), Cardin et al.
patent: 5674906 (1997-10-01), Hatanaka et al.
patent: 5686478 (1997-11-01), Greenlee et al.
patent: 5705530 (1998-01-01), Adorante et al.
patent: 5716928 (1998-02-01), Benet et al.
patent: 5731353 (1998-03-01), Ohsumi et al.
patent: 5733909 (1998-03-01), Black et al.
patent: 5767268 (1998-06-01), Chucholowski et al.
patent: 5770620 (1998-06-01), Mjalli et al.
patent: 5827898 (1998-10-01), Khandwala et al.
patent: 6245814 (2001-06-01), Nag et al.
patent: 6262118 (2001-07-01), Luskey et al.
patent: 6331633 (2001-12-01), Neogi et al.
patent: 6525093 (2003-02-01), Neogi et al.
patent: 6624197 (2003-09-01), Nag et al.
patent: 6646004 (2003-11-01), Luskey et al.
patent: 6855732 (2005-02-01), Neogi et al.
patent: 7105552 (2006-09-01), Nag et al.
patent: 0332331 (1989-09-01), None
patent: 2254549 (1975-07-01), None
patent: 1496156 (1977-12-01), None
patent: 09059245 (1997-03-01), None
patent: 97/25042 (1997-07-01), None
patent: 99/50263 (1999-10-01), None
patent: 99/56737 (1999-11-01), None
patent: 00/69430 (2000-11-01), None
patent: WO 01/34094 (2001-05-01), None
patent: 01/95859 (2001-12-01), None
patent: 02/02501 (2002-01-01), None
Pettit et al., “Isolation, Structure, Synthesis and Antimitotic Properties of Combretasttins B-3 and B-4 from Combretum Caffrum”Journal of Natural Products51:3 (1998) pp. 517-527.
Green, R. H., “Syntheses of Differanisole A”Tetrahedron Letters38:26 (1997) pp. 4697-4700.
Reddy et al., “From Styrenes to Enanitopure α-Arylglycines in Two Steps”J. Am. Chem. Soc., 120:6, (1998) pp. 1207-1217.
Sheehan et al., “A Constituent ofPtercarpus marsupium, (−)-Epicatechin, as a Potential Antidiabetic Agent,”Journal of Natural Products, 46:2 (1983) pp. 232-234.
He et al., “Spectrometric Study of α-Phenylcinnamic Acids,”Chinese Chemical Letters, 8:10 (1997) pp. 883-884.
Chakravarthy et al., “The Prophylactic Action of (−)-Epicatechin Against Alloxan Induced Diabetes in Rats,”Life Science, 29 (1981) pp. 2043-2047.
Farboodniay et al., “Antihyperglycemic Effect of Flavonoids FromPtercarpus marsupium,” Journal of Natural Products, 56:7 (1993) pp. 989-994.
Manickham et al., “AntihyperLipidemic Activity of Phenolics fromPtercarpus marsupium,” Journal of Natural Products, 6:60 (1997) pp. 609-610.
Maurya et al., “Constituents ofPtercarpus marsupium,” Journal of Natural Products, 47:1 (1983) pp. 179-181.
Maurya et al., “Marsupsin, a New Benzofuranone fromPterocarpus marsupiumROXB.,”Heterocylces, 19:11 (1982) pp. 2103-2107.
Online Database, Chemical Abstracts Service, Database accession No. 1941:25276, Spath et al. (1941) pp. 189-192.
Sullivan et al., “The Absolute Configuration of α-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane,d-Propoxyphene,”Journal of Organic Chemistry, 28:9 (1963) pp. 2381-2385.
Jacobsen et al.,Journal of Organic Chemistry, 44:22 (1979) pp. 4013-4014.
Ryu et al., “Antitumor Activity of some Phenolic Components in Plants,”Archives of Pharmaceutical Research, 17:1 (1994) pp. 42-44.
Jang et al., “Inhibitory Effects of Resveratrol Analogs on Unopsonized Zymosan-Induced Oxygen Radical Production”,Biochemical Pharmacology, vol. 57 (1999) pp. 705-712.
Setala et al., “A Novel Type of Spiro Compound Formed by Oxidative Cross Coupling of Methyl Sinapate with a Syringyl Lignin Model Compound. A Model System for the .β.-1 Pathway in Lignin Biosysthesis,”Journal of the Chemical Society, Perkin Trans., vol. 4 (1999) pp. 461-464.
Hulin et al., “Novel Thiazolidone-2,4-diones as Potent Euglycemic Agents,”J. Med. Chem., vol. 35 (1992) 1853-64.
Sohda et al., “Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and Its derivatives”Chemical&Pharmaceutical Bulletin, 30:10 (1982) pp. 3580-3600.
Sohda et al., “Antiulcer activity of 5-Benzylthiazolidine-2,4-dione Derivatives,”Chemical&Pharmaceutical Bulletin, 31:2 (1983) pp. 560-569.
Unangst et al., “Synthesis and biological evaluation of 5-[[3,5-Bis(1,1dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles,-thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cycloxygenase Inhibitors with Antiinflammatory Activity,”Journal of Medicinal Chemistry, 37:2 (1994) pp. 322-328.
Chen Liang
Dey Debedranath
Fuller Joseph
Li Ta-Kai
Neogi Partha
Jones Day
Saeed Kamal A.
Theracos, Inc.
LandOfFree
Compounds for treatment of inflammation, diabetes and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds for treatment of inflammation, diabetes and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for treatment of inflammation, diabetes and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2805790