Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-25
2006-07-25
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S211080, C540S575000, C544S008000
Reexamination Certificate
active
07081453
ABSTRACT:
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharma-ceutically acceptable acid addition salt thereof, wherein —a1═a2—a3═a4— is a bivalent radical wherein one or two of a1to a4are nitrogen and the remaining a1to a4are —CH═; —Z1—Z2— is a bivalent radical; —A— is a bivalent radical of formula —N(R6)—Alk2— or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms; R1, R2and R3are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; Alk1and Alk2are optionally substituted C1-6alkanediyl; R5is a radical of formula (d-1), (d-2), (d-3), (d-4), (d-5) wherein n is 1 or 2; p1is 0, and p2is 1 or 2; or p1is 1 or 2, and p2is 0; X is oxygen, sulfur or ═NR9; Y2is oxygen or sulfur; R7is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to disturbed fundic accomodation
REFERENCES:
patent: 3910930 (1975-10-01), Jansen
patent: 0 004 358 (1982-01-01), None
patent: WO 93/17017 (1993-09-01), None
patent: WO 97/28157 (1997-08-01), None
patent: WO 99/29687 (1999-06-01), None
patent: WO 00/75136 (2000-12-01), None
patent: WO 00/75137 (2000-12-01), None
PCT Search Report re International Application No. PCT/EP01/06749.
Alcázar-Vaca Manuel Jesús
Andrés-Gil José Ignacio
Bartolomé-Nebreda José Manuel
De Bruyn Marcel Frans Leopold
Fernández-Gadea Francisco Javier
Janssen Pharmaceutica N.V.
Johnsen Jason H.
Wilson James O.
LandOfFree
Compounds for treating impaired fundic relaxation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds for treating impaired fundic relaxation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for treating impaired fundic relaxation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3596461