Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-02-16
2008-09-09
Balasubram, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S256000, C514S252120, C514S218000, C514S212010, C546S115000, C540S484000, C540S575000, C544S316000, C544S359000
Reexamination Certificate
active
07423048
ABSTRACT:
The present invention concerns compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a1═a2-a3═a4- is a bivalent radical wherein one or two of a1to a4are nitrogen and the remaining a1to a4are —CH═; -Z1-Z2- is a bivalent radical; -A- is a bivalent radical of formula —N(R6)-Alk2- or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms; R1, R2and R3are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; Alk1and Alk2are optionally substituted C1-6alkanediyl; R5is a radical of formulawherein n is 1 or 2; p1is 0, and p2is 1 or 2; or p1is 1 or 2, and p2is 0; X is oxygen, sulfur or ═NR9; Y2is oxygen or sulfur; R7is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9is cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to disturbed fundic accomodation.
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Alcázar-Vaca Manuel Jesús
Andrés-Gil José Ignacio
Bartolomé-Nebreda José Manuel
De Bruyn Marcel Frans Leopold
Fernández-Gadea Francisco Javier
Balasubram Venkataraman
Janssen Pharmaceutica N.V.
Woodcock & Washburn LLP
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