Compounds for treating cocaine abuse

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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558418, 558422, C07C21142

Patent

active

058213864

ABSTRACT:
Disclosed are novel compounds which are dopamine reuptake blockers for treating cocaine abuse. The compounds are represented by the following structural formula: ##STR1## R2 is n-propyl, iso-propyl, n-butyl, sec-butyl, or tert-butyl. Phenyl Ring B is unsubstituted or substituted with one, two or three substituents.

REFERENCES:
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N. Tomita, "Structure-Actuvuty Relationaships of dopamine-a nd Norepinephrine-Uptake Inhibitors," Chem. Pharm. Bull. 38(6):1563-1569 (1990).
M. Froimowitz, et al., "Slow Onset, Long Lasting Dopamine Reuptake Blockers as Potential Medications for the Treatment of Cocaine Abuse," 1996 Annual Meeting, Washington, D.C., Nov. 16-21, 1996, Abstract, Mail Date: Aug. 18, 1996.
M. Froimowitz, et a;., "Effects of a Slow-Onset, Long-Acting Dopamine Reuptake Blocker on Cocaine Self-Administration and on Nucleus Accumbers Dopamine," Society for Neuroscience Abstracts, vol. 23, Part 1, 27.sup.th Annual Meeting, New Orleans, LA, Oct. 25-30, 1997, Mail Date: Aug. 25, 1997.
Agenda for oral presentation at the National Instistute in Drug Abuse National Instistutes of Health Meeting entitled, "Cocaine Medications-Better Treatment Through chemistry," Scientific Meeting at the National Instistute on Drug Abuse, Apr. 29-30, 1996.
Elliot L. Gardner, et al., Poster presented at meetings of the College on Problems of Drug Dependence, Nashville, Tennessee, Jun. 1997.

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