Compounds for the treatment of proliferative disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S212000

Reexamination Certificate

active

07572821

ABSTRACT:
The invention relates to compounds of structural formula (I):or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.

REFERENCES:
patent: 5840746 (1998-11-01), Ducharme et al.
patent: WO 2004/035553 (2004-04-01), None
Cancer, Wikipedia.
Gauthier, Jacques Yves, et al. “Synthesis and Biological Evaluation of 2,3-Diarylthiophenes as Selective Cox-2 Inhibitors. Part II: Replacing the Heterocycle,”Bioorganic&Medicinal Chemistry Letters, 6(1): 87-92 (1996).

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