Compounds for the treatment of pneumocystis carinii Pneumonia, G

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544296, 544298, 544319, 544322, 544335, C07D23926

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active

056060580

ABSTRACT:
The present invention provides compounds useful for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The compounds comprise compounds of Formula I: ##STR1##

REFERENCES:
patent: 4727073 (1988-02-01), Takaya et al.
B. P. Das et al.; 1-4-Bis(4guanylphenylethyl)benzenes as Potential Antitrypanosomal Agents, Journal of Pharmaceutical Sciences 71: pp. 465-466 (1982).
B. P. Das et al; Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)furans, Journal of Medicinal Chemistry, 20, pp. 531-536 (1977).
B. P. Das et al; Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)thiophenes and--pyrroles, Journal of Medicinal Chemistry 20, pp. 1219-1221 (1977).
B. P. Das et al; Synthesis and Antitrypanosomal Activity of Some Bis(4-guanylphenyl) Five-and Six-Membered Ring Heterocycles, J. Med. Chem. 23, pp. 578-581 (1980).
C. C. Dykstra et al; Synthesis and Characterization of a Novel Series of Aromatic Dicationic Furans With DNA-Specific Fluorescence Properties, pp. 1-7 (1994).
D. E. Rooney et al; Human Cytogenetics: A Practical Approach, ed. IRL Press, Oxford University Press, selected pages (1992).

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