Compounds for the treatment of metabolic disorders

Details Compounds for the treatment of metabolic disorders Compounds for the treatment of metabolic disorders

2004-04-20

2008-10-28

Weddington, Kevin E (Department: 1614)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S329000, C560S008000, C560S019000, C560S039000, C560S075000

Reexamination Certificate

active

07442796

ABSTRACT:
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0 to 4; q is 0 or 1; t is 0 or 1; R2is alkyl having from 1 to 3 carbon atoms; R3is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalendy bound to the remainder of the compound of formula (I) by a ring carbon; and R1is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).

REFERENCES:
patent: 4474809 (1984-10-01), Floyd, Jr. et al.
patent: 5453443 (1995-09-01), Perrier et al.
patent: 5589492 (1996-12-01), Haigh
patent: 5665387 (1997-09-01), Mathieu et al.
patent: 6211234 (2001-04-01), Astles et al.
patent: 6858602 (2005-02-01), Sharma et al.
patent: 6916848 (2005-07-01), Sharma
patent: 6924314 (2005-08-01), Sharma et al.
patent: 6946491 (2005-09-01), Sharma et al.
patent: 7012071 (2006-03-01), Sharma et al.
patent: 7041659 (2006-05-01), Sharma
patent: 7045541 (2006-05-01), Sharma
patent: 7101910 (2006-09-01), Sharma
patent: 2002/0028943 (2002-03-01), Griffin
patent: 2005/0090555 (2005-04-01), Sharma et al.
patent: 2005/0256333 (2005-11-01), Sharma et al.
patent: 2006/0014784 (2006-01-01), Hodge et al.
patent: 2006/0035970 (2006-02-01), Hodge et al.
patent: 2006/0247309 (2006-11-01), Hodge et al.
patent: 2007/0105955 (2007-05-01), Hodge et al.
patent: 2007/0105958 (2007-05-01), Sharma et al.
patent: WO 9911255 (1999-03-01), None
patent: WO02/100341 (2002-12-01), None
Younis, et al., “The prevention of type 2 diabetes mellitus: recent advances”, QJ Med., vol. 97, pp. 451-455, 2004.
Goff, et al., “Prevention of Cardiovascular Disease in Persons with type 2 diabetes Mellitus: Current Knowledge and Rational for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial”, AM J Cardiol., 99(12A): S4-S20, 2007. (Abstract).
Knowler, et al., “Perspectives in Diabetes: Preventing Non-Insulin-Dependent Diabetes”, Diabetes, vol. 44, pp. 483-488, 1995.
Pending (as of Aug. 20, 2007) claims from U.S. Appl. No. 11/481508.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772501.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772504.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772511.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772515.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772520.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772556.
Pending (as of Jul. 2, 2007) claims from U.S. Appl. No. 11/772560.
Pending (as of Aug. 24, 2007) claims from U.S. Appl. No. 11/844431.
Pending (as of Aug. 24, 2007) claims from U.S. Appl. No. 11/844432.
Pending (as of Aug. 20, 2007) claims from U.S. Appl. No. 11/841489.
Pending (as of Sep. 20, 2007) claims from U.S. Appl. No. 10/566302.
Pending (as of Sep. 19, 2007) claims from U.S. Appl. No. 11909120.
Pending claims from U.S. Appl. No. 10/531,618, filed Apr. 14, 2005.

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