Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2008-04-22
2008-04-22
Puttlitz, Karl (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S532000, C514S534000, C560S070000, C560S070000, C562S433000, C562S471000
Reexamination Certificate
active
10553936
ABSTRACT:
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; q is 0 or 1; t is 0 or 1; R2is alkyl having from 1 to 3 carbon atoms; R3is hydrogen, halo, alkyl having from 1 to 3 atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R1is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I)
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Hodge Kirvin L.
Kaufman Robert
Lee Albert C.
Sharma Shalini
von Borstel Reid W.
Kreisler Lewis J.
Puttlitz Karl
Valenrod Yevgeny
Wellstat Therapeutics Corporation
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