Compounds for the treatment of inflammatory disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S406000, C514S414000, C548S209000, C548S361500, C548S465000

Reexamination Certificate

active

07488745

ABSTRACT:
This invention relates to compounds of the Formula (I):or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

REFERENCES:
patent: 2006/0276506 (2006-12-01), Yu
patent: WO02/074750 (2002-09-01), None
patent: WO02/096426 (2002-12-01), None
patent: WO2004/024721 (2004-03-01), None
patent: WO2006/019768 (2006-02-01), None
patent: WO2007/084455 (2007-07-01), None
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International Search Report for International Application No. PCT/US2007/000930 dated Aug. 22, 2007.
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Morimoto, Yasuo et. al., A Novel Matrix Metalloproteinase Inhibitor, Exerts Its Antidiabetic Effect By Inhibiting Tumor Necrosis Factor-α Production; Life Sciences, 1997, 61(8), 795-803.
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Satoh , Mamoru et. al., Expression of Tumor Necrosis Factor-alpha-Converting Enzyme and Tumor Necrosis Factor-alpha in Human Myocarditis; Journal of the American College of Cardiology, 2000, 36(4), 1288-1294.
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Togashi, Nobuhiko, et. al.; Effect o TNF-α-Converting Enzyme Inhibitor on Insulin Resistance in Fructose-Fed Rats; Hypertension, 2002, 39(part 2), 578-580.
Trifilieff, Alexandre et. al.,Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF—α converting enzyme and matrix metalloproteinases, in models of airway inflammation; British Journal of Pharmacology, 2002, vol. 135(7), 1655-1664.
Van Deventer, SJH; A place for TACE; GUT 2002 51: 5-6.

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