Compounds for the prevention and treatment of helmith infections

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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4241931, 4241841, 4242801, 514 2, 514 12, 540575, A61K 39385, A61K 3939, A61K 3800, C07D24308

Patent

active

058111000

ABSTRACT:
A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier to which the hyaluronidase is covalently coupled comprising a copolymer of ethylenepiperazine N-oxide and N-ethylacetylethylenepiperazinium bromide (hereafter referred to as "SYNPOL"), and a process for protecting a vertebrate against infection by helminths comprising administration to the vertebrate of a therapeutically effective amount of a compound comprising hyaluronidase covalently coupled to an immunostimulating carrier, preferably SYNPOL, in preferred form, the compound being administered to the vertebrate in the form of a vaccine.

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Attached Search Chemical Registry.
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Fiszer-Szafarz. 1984. Hgaluronidase Polymorphism Detected by PolyarcylamideGel . . . Analytical Biochem. 143:76-81.
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Lovgren et al. 1991. The Iscom: An Antigen Delivery System with Built-in Adjuvant Mol.Immunol. 28(3):285-286.
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Khaitov, Annals Ny Acad. Sci. 685:788-802, 1993.

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