Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-05
1996-09-17
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D49300
Patent
active
055569935
ABSTRACT:
Psoralen compounds are synthesized which have substitutions on the 4,4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
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Isaacs Stephen T.
Nerio Aileen
Rapoport Henry
Spielmann Hans P.
Wollowitz Susan
Carroll Peter G.
Ivy C. Warren
Owens Amelia
Steritech, Inc.
Wilke Kathryn P.
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