Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-03-29
2011-03-29
Bowman, Amy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300, C536S024310, C536S024330, C514S04400A
Reexamination Certificate
active
07915401
ABSTRACT:
The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancer. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of beta-catenin using said oligomers, including methods of treatment.
REFERENCES:
patent: 4914210 (1990-04-01), Levenson et al.
patent: 4962029 (1990-10-01), Levenson et al.
patent: 6066500 (2000-05-01), Bennett et al.
patent: 7087229 (2006-08-01), Zhao et al.
patent: 2003/0064384 (2003-04-01), Hung et al.
patent: 2004/0235773 (2004-11-01), Zhao et al.
patent: 2009/0005335 (2009-01-01), Worm
patent: 1222309 (2005-12-01), None
patent: 01/00872 (2001-01-01), None
patent: WO2004/046160 (2004-06-01), None
patent: WO2007/031081 (2007-03-01), None
patent: WO2007/031091 (2007-03-01), None
patent: WO2007/146511 (2007-12-01), None
patent: WO2008/034123 (2008-03-01), None
patent: WO2008/053314 (2008-05-01), None
Veeramachanemi N.K. et al.: “Down-regulation of beta catenin inhibits the growth of esophageal carcinoma cells”. The Journal of Thoracic and Cardiovascular Surgery, vol. 127, pp. 92-98, Jan. 2004.
Roh H. et al.: “Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells”. Cancer Research, vol. 61, pp. 6563-6568, Sep. 1, 2001.
Canter R.J. et al.: “Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer”. Annals of Surgical Oncology, vol. 12, No. 9, pp. 733-742, Sep. 1, 2005.
Green D.W. et al.: “Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts” Journal of Surgical Research, vol. 101, pp. 16-20, 2001.
Emanuele S. et al.: “Sodium Butyrate induces apoptosis in human epatoma cells by a mitochondrial/caspase pathway, associated with degradation of beta-catenin, PRb and Bcl-XL” European Journal of Cancer, vol. 40, pp. 1441-1452, 2004.
Li M. et al.: “Antitumor activity and chemosensitization effects of novel antisense oligonucleotides targeting beta-catenin”. Proceedings of the American Association for Cancer Research Annual Meeting, vol. 46, p. 137, Apr. 2005.
Heasman J. et al.: “Overexpression of Cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos”. Cell, vol. 79, No. 5, pp. 791-803, Dec. 1994.
Kim K. et al.: “Tissue-specific expression of beta-catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness”. Experimental Cell Research, vol. 245, pp. 79-90, Jan. 1998.
International Preliminary Report on Patentability and Written Opinion issued in PCT/EP2008/055365 and dated Nov. 3, 2009.
International Search Report issued in PCT/EP2008/055365 and dated May 7, 2009.
Christensen, et al., “Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA,”Nucleic Acids Research, vol. 30, No. 22, pp. 4918-4925 (2002).
de La Coste, et al., “Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas,”Proc. Natl. Acad. Sci. USA, vol. 95, pp. 8847-8851 (1998).
Freier, et al., “The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes,”Nucleic Acids Research, vol. 25, No. 22, pp. 4429-4443 (1997).
Manoharan, et al., “Novel Functionalization of the Sugar Moiety of Nucleic Acids for Multiple Labeling in the Minor Groove,”Tetrahedron Letters, vol. 32, No. 49, pp. 7171-7174 (1991).
Morin, et al., Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutation in β-Catenin or APC, Science, vol. 275, pp. 1787-1790 (1997).
U.S. Appl. No. 60/915,371, filed May 1, 2007.
U.S. Appl. No. 60/977,409.
U.S. Appl. No. 61/023,244, filed Jan. 24, 2008.
Powell, et al., “APCmutations occur early during colorectal tumorigenesis,”Nature, vol. 359, p. 235-237 (1992).
Rubinfeld, et al., “Stabilization on β-Catenin by Genetic Defects in Melanoma Cell Lines,”Science, vol. 275, p. 1790-1792 (1997).
Sparks, et al., “Mutational Analysis of the APC/β-Catenin-Tcf Pathway in Colorectal Cancer,” Cancer Research, Vo. 58, pp. 1130-1134 (1998).
Uhlmann, “Recent advances in the medicinal chemistry of antisense oligonucleotides,”Current Opinion in Drug Discovery&Development, vol. 3, No. 2, pp. 203-213 (2000).
Zhao, et al., “Delivery of G3139 using releasable PEG-linkers: Impact on pharmacokinetic profile and anti-tumor efficacy,”Journal of Controlled Release, vol. 119, pp. 143-152 (2007).
Zhao, et al., “A New Platform for Oligonucleotide Delivery Utilizing the PEG Prodrug Approach,”Bioconjugate Chem., vol. 16, pp. 758-766 (2005).
Zhang, Y. et al., In vitro and in vivo characterization of two novel beta-catenin RNA antagonists, EZN-3889 and EZN-3892. Enzon Pharmaceuticals, Inc. AACR Poster, Washington, D.C. 2010.
Xu et al., Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs. Biochemical and Biophysical Research Communications, May 2003, 306, pp. 712-717.
Bowman Amy
Enzon Pharmaceuticals, Inc.
Lucas & Mercanti LLP
Santaris Pharma A/S
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